Decreased vesicular acetylcholine transporter and α4β2 nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning

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dc.contributor.authorQuinlivan, Men_AU
dc.contributor.authorChalon, Sen_AU
dc.contributor.authorVergote, Jen_AU
dc.contributor.authorHenderson, Jen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.contributor.authorKassiou, Men_AU
dc.contributor.authorGuilloteau, Den_AU
dc.date.accessioned2014-03-30T21:53:34Zen_AU
dc.date.available2014-03-30T21:53:34Zen_AU
dc.date.issued2007-03-26en_AU
dc.date.statistics2014-03-31en_AU
dc.description.abstractDegeneration of cholinergic neurons is a well known characteristic of Alzheimer's disease (AD). Two radioligands were studied in a rat model of cholinergic degeneration to evaluate their potential efficacy for molecular imaging of AD. Following specific cholinergic-cell immunolesioning with 192 IgG-saporin (SAP), ex vivo autoradiography was performed with 123IBVM, a radioligand which targets the vesicular acetylcholine transporter (VAChT). Following the decay of 123I, the same animals had in vitro autoradiography performed with 125I-A-85380, a marker for nicotinic acetylcholine receptors (nAChRs). As expected significant, widespread decreases in 123IBVM uptake were observed in SAP treated animals. Moderate but significant reductions in 125I-A-85380 binding in the hippocampus (Hip) and cerebellum (Cbm) were also observed following SAP immunolesioning. The results with 123IBVM confirm and extend previous work investigating the uptake of radioiodinated IBVM in this animal model. The results with 125I-A-85380 are unique and are in contrast with work performed in this animal model with other nAChR radioligands, indicating the favourable properties of this radioligand for molecular imaging. © 2006 Elsevier Ireland Ltd.en_AU
dc.identifier.citationQuinlivan, M., Chalon, S., Vergote, J., Henderson, J., Katsifis, A., Kassiou, M., & Guilloteau, D. (2007). Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Neuroscience Letters, 415(2), 97-101. doi:10.1016/j.neulet.2006.08.065en_AU
dc.identifier.govdoc4537en_AU
dc.identifier.issn0304-3940en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleNeuroscience Lettersen_AU
dc.identifier.pagination97-101en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.neulet.2006.08.065en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5356en_AU
dc.identifier.volume415en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectReceptorsen_AU
dc.subjectAcetylcholineen_AU
dc.subjectBrainen_AU
dc.subjectNeuroregulatorsen_AU
dc.subjectNicotinic aciden_AU
dc.subjectAutoradiographyen_AU
dc.subjectHippocampusen_AU
dc.titleDecreased vesicular acetylcholine transporter and α4β2 nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioningen_AU
dc.typeJournal Articleen_AU
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