Opposing short- and long-term effects on muscarinic M1/4 receptor binding following chronic phencyclidine treatment

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dc.contributor.authorNewell, KAen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2014-04-28T01:14:19Zen_AU
dc.date.available2014-04-28T01:14:19Zen_AU
dc.date.issued2007-05-01en_AU
dc.date.statistics2014-04-28en_AU
dc.description.abstractPhencyclidine (PCP) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Several studies have demonstrated that chronic NMDA receptor antagonist treatment in humans and animals can cause long-term behavioral changes that are reminiscent of negative and cognitive schizophrenia-like symptoms. The muscarinic cholinergic system, which is associated with cognitive functions, has been hypothesized to contribute to PCP's mechanism of action. No study, however, has examined the status of M1/4 receptors in the PCP model of schizophrenia. The aim of the present study was to investigate the effects of chronic (14 day) PCP treatment on mouse brain M1/4 receptors in the short term (1 hr and 24 hr) and long term (14 days) after last PCP administration. [3H]pirenzepine was used to target M1/4 receptors. In the short term following chronic PCP treatment, M1/4 binding was significantly increased in regions of the limbic system, caudate-putamen, cortex, and thalamus (ranging from 56% to 368%), compared with saline-treated mice. There were no differences in binding between mice treated with PCP for 14 days and sacrificed 1 hr or 24 hr after the final PCP treatment. In the long term following chronic PCP treatment, M1/4 binding was significantly decreased in all of the above-mentioned brain regions (ranging from 31% to 72%), except in the thalamus, which showed no change. These findings in the long-term group are similar to those reported in post-mortem studies of patients suffering from schizophrenia. © 2007, John Wiley & Sons, Inc.en_AU
dc.identifier.citationNewell, K. A., Zavitsanou, K., & Huang, X. F. (2007). Opposing short- and long-term effects on muscarinic M1/4 receptor binding following chronic phencyclidine treatment. Journal of Neuroscience Research, 85(6), 1358-1363. doi:10.1002/jnr.21247en_AU
dc.identifier.govdoc4535en_AU
dc.identifier.issn0360-4012en_AU
dc.identifier.issue6en_AU
dc.identifier.journaltitleJournal of Neuroscience Researchen_AU
dc.identifier.pagination1358-1363en_AU
dc.identifier.urihttp://dx.doi.org/10.1002/jnr.21247en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5500en_AU
dc.identifier.volume85en_AU
dc.language.isoenen_AU
dc.publisherWiley-Lissen_AU
dc.subjectReceptorsen_AU
dc.subjectRatsen_AU
dc.subjectAutoradiographyen_AU
dc.subjectAnimalsen_AU
dc.subjectBrainen_AU
dc.subjectAtropineen_AU
dc.titleOpposing short- and long-term effects on muscarinic M1/4 receptor binding following chronic phencyclidine treatmenten_AU
dc.typeJournal Articleen_AU
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