Immunohistochemical localisation of the NK1 receptor in the human amygdala: Preliminary investigation in schizophrenia

Simple item page
dc.contributor.authorWeidenhofer, Jen_AU
dc.contributor.authorYip, Jen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.contributor.authorHuang, XFen_AU
dc.contributor.authorChahl, LAen_AU
dc.contributor.authorTooney, PAen_AU
dc.date.accessioned2014-06-26T05:32:52Zen_AU
dc.date.available2014-06-26T05:32:52Zen_AU
dc.date.issued2006-09-30en_AU
dc.date.statistics2014-06-26en_AU
dc.description.abstractThe amygdala has a role in the modulation of moods and emotion, processes that are known to be affected in people wi th psychiatric disorders such as schizophrenia and depression. The tachykinin NK1 receptor is known to be expressed in the amygdala. However to date, there is limited knowledge of the distribution of the NK1 receptor in this region. This study used immunohistochemistry to analyse the distribution of the NK1 receptor in fixed human amygdala tissue in control subjects with no history of psychiatric illness and matched subjects with a diagnosis of schizophrenia (n = 4 pairs). The NK1 receptor was observed sparsely distributed in cell bodies in all amygdaloid nuclei with the basolateral and lateral having a greater relative density of NK1 receptor-immunoreactive cell bodies than the other nuclei. Double labelling with antibodies to microtubule associated protein and the NK1 receptor revealed that the NK1 receptor is expressed by large pyramidal, small stellate and large bipolar neurons. Interestingly, the basal nucleus of Meynert, which is just dorsal to the amygdala, was observed to have a significantly higher relative density of NK1 receptor-immunoreactive cell bodies compared to any of the amygdaloid nuclei. Preliminary analysis of the density of NK1 receptor-immunoreactive cell bodies in the major amygdaloid nuclei and the basal nucleus of Meynert revealed no significant differences between schizophrenia and control subjects. Real-time PCR showed that the mRNA for both the short and long isoforms of the NK1 receptor was expressed at low levels in fresh frozen human amygdala tissue from control subjects and that this was not different in matched subjects with schizophrenia (n = 11 pairs). In conclusion, this study has demonstrated that the NK1 receptor is widely distributed in the amygdala, and has shown for the first time a high relative density of NK1 receptor-immunoreactive cell bodies in the basal nucleus of Meynert. © 2006, Elsevier Ltd.en_AU
dc.identifier.citationWeidenhofer, J., Yip, J., Zavitsanou, K., Huang, X. F., Chahl, L. A., & Tooney, P. A. (2006). Immunohistochemical localisation of the NK1 receptor in the human amygdala: Preliminary investigation in schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30(7), 1313-1321. doi:10.1016/j.pnpbp.2006.05.008en_AU
dc.identifier.govdoc4528en_AU
dc.identifier.issn0278-5846en_AU
dc.identifier.issue7en_AU
dc.identifier.journaltitleProgress in Neuro-Psychopharmacology & Biological Psychiatryen_AU
dc.identifier.pagination1313-1321en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.pnpbp.2006.05.008en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5723en_AU
dc.identifier.volume30en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectGuinea pigsen_AU
dc.subjectRodentsen_AU
dc.subjectCerebral cortexen_AU
dc.subjectBrainen_AU
dc.subjectBehavioren_AU
dc.subjectReceptorsen_AU
dc.titleImmunohistochemical localisation of the NK1 receptor in the human amygdala: Preliminary investigation in schizophreniaen_AU
dc.typeJournal Articleen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles