Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain

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dc.contributor.authorHuang, XFen_AU
dc.contributor.authorHan, Men_AU
dc.contributor.authorHuang, Xen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.contributor.authorDeng, Cen_AU
dc.date.accessioned2014-05-11T22:53:29Zen_AU
dc.date.available2014-05-11T22:53:29Zen_AU
dc.date.issued2006-08-10en_AU
dc.date.statistics2014-05-09en_AU
dc.description.abstractThis study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT2C receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT2A receptor mRNA expression and total food intake, weight gain and energy efficiency were observed. © 2006, Elsevier Ltd.en_AU
dc.identifier.citationHuang, X. F., Han, M., Huang, X., Zavitsanou, K., & Deng, C. (2006). Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain. Behavioural Brain Research, 171(2), 355-362. doi:10.1016/j.bbr.2006.03.040en_AU
dc.identifier.govdoc4524en_AU
dc.identifier.issn0166-4328en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleBehavioural Brain Researchen_AU
dc.identifier.pagination355-362en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.bbr.2006.03.040en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5564en_AU
dc.identifier.volume171en_AU
dc.language.isoenen_AU
dc.publisherElsevier Science BVen_AU
dc.subjectWeighten_AU
dc.subjectMetabolic diseasesen_AU
dc.subjectDopamineen_AU
dc.subjectSerotoninen_AU
dc.subjectGenesen_AU
dc.subjectDieten_AU
dc.titleOlanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brainen_AU
dc.typeJournal Articleen_AU
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