GABAA receptor density is altered by cannabinoid treatment in the hippocampus of adult but not adolescent rats.

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dc.contributor.authorVerdurand, Men_AU
dc.contributor.authorDalton, VSen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2010-09-27T01:38:06Zen_AU
dc.date.available2010-09-27T01:38:06Zen_AU
dc.date.issued2010-09-10en_AU
dc.date.statistics2010-09-10en_AU
dc.description.abstractCannabinoids are known to induce transient psychotic symptoms and cognitive dysfunction in healthy individuals and contribute to trigger schizophrenia in vulnerable individuals, particularly during adolescence. Converging preclinical evidence suggests important interactions between cannabinoid and GABAergic systems. In the present study, we compared the effects of cannabinoid treatment on GABAA receptor binding in the brain of adolescent and adult rats. Adolescent (5weeks old) and adult (10weeks old) rats were treated with the synthetic cannabinoid HU210 (25, 50 or 100I14g/kg/day) or vehicle for 1, 4 or 14days. Rats were sacrificed 24h after the last injection and GABAA receptor density was measured in several brain regions using [35S]TBPS and in vitro autoradiography. Adolescent rats had higher numbers of GABAA receptors compared to adults. A 24% increase of binding in adult rats treated with 100I14g/kg HU210 for 14days compared to controls was observed in the CA1 region of the hippocampus (16.1 versus 12.9fmol/mg tissue equivalent, t =2.720, p <0.05). HU210 did not affect GABAA receptors in adolescent rats in any treatment regimen and in adult rats treated with HU210 for 1 or 4days. These data suggest that long-term, high-dose treatment with HU210 increases GABAA receptors in the hippocampus of adult rats, changes that may interfere with associated hippocampal cognitive functions such as learning and memory. In addition, our results suggest that the adolescent brain does not display the same compensatory mechanisms that are activated in the adult brain following cannabinoid treatment. © 2010, Elsevier Ltd.en_AU
dc.identifier.citationVerdurand, M., Dalton, V. S., & Zavitsanou, K. (2010). GABAA receptor density is altered by cannabinoid treatment in the hippocampus of adult but not adolescent rats. Brain Research, 1351, 238-245. doi:10.1016/j.brainres.2010.06.032en_AU
dc.identifier.govdoc2723en_AU
dc.identifier.issn0006-8993en_AU
dc.identifier.journaltitleBrain Researchen_AU
dc.identifier.pagination238-245en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.brainres.2010.06.032en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2563en_AU
dc.identifier.volume1351en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectHippocampusen_AU
dc.subjectRatsen_AU
dc.subjectMental disordersen_AU
dc.subjectAdolescentsen_AU
dc.subjectAutoradiographyen_AU
dc.subjectReceptorsen_AU
dc.titleGABAA receptor density is altered by cannabinoid treatment in the hippocampus of adult but not adolescent rats.en_AU
dc.typeJournal Articleen_AU
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