An investigation into the potential of SarAr for use in Cu-64 radioimmunotherapy.

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dc.contributor.authorDi Bartolo, Nen_AU
dc.contributor.authorSmith, SVen_AU
dc.contributor.authorHetherington, ELRen_AU
dc.contributor.authorSargeson, Aen_AU
dc.date.accessioned2010-04-05T23:47:56Zen_AU
dc.date.accessioned2010-04-30T05:09:05Zen_AU
dc.date.available2010-04-05T23:47:56Zen_AU
dc.date.available2010-04-30T05:09:05Zen_AU
dc.date.issued2009-10-13en_AU
dc.date.statistics2009-10-13en_AU
dc.description.abstractThe B72.3 monoclonal antibody was radiolabelled with 123I, and with 111In and 64Cu, using DTPA and SarAr, respectively. Their biodistribution in tumour-bearing nude mice was used to calculate the dosimetry of their respective therapeutic analogue, using 131I, 90Y, 67Cu, and 64Cu. Two dosimetry models were used: one using the classical approach and a second model that takes into consideration the chemical stability of the radiolabelling methods employed and the biological clearance of each radioimmunoconjugate. Results clearly show that the 64Cu-SarAr-B72.3 could be used as a therapeutic agent and, theoretically, be at least as effective as any of the other therapeutic radionuclides currently studied, such as 131I, 90Y, and 67Cu. © 2009, CSIRO Publishingen_AU
dc.identifier.citationDi Bartolo, N., Smith, S. V., Hetherington, E., & Sargeson, A. (2009). An investigation into the potential of SarAr for use in Cu-64 radioimmunotherapy. Australian Journal of Chemistry, 62(10), 1261-1270. doi:10.1071/CH09369en_AU
dc.identifier.govdoc1585en_AU
dc.identifier.issn0004-9425en_AU
dc.identifier.issue10en_AU
dc.identifier.journaltitleAustralian Journal of Chemistryen_AU
dc.identifier.pagination1261-1270en_AU
dc.identifier.urihttp://dx.doi.org/10.1071/CH09369en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3029en_AU
dc.identifier.volume62en_AU
dc.language.isoenen_AU
dc.publisherCSIRO Publishingen_AU
dc.subjectRadioimmunotherapyen_AU
dc.subjectIodine 123en_AU
dc.subjectCopper 64en_AU
dc.subjectMiceen_AU
dc.subjectDosimetryen_AU
dc.subjectDrugsen_AU
dc.titleAn investigation into the potential of SarAr for use in Cu-64 radioimmunotherapy.en_AU
dc.typeJournal Articleen_AU
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