Synthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studies

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dc.contributor.authorMusumeci, AWen_AU
dc.contributor.authorSchiller, TLen_AU
dc.contributor.authorXu, ZPen_AU
dc.contributor.authorMinchin, RFen_AU
dc.contributor.authorMartin, DJen_AU
dc.contributor.authorSmith, SVen_AU
dc.date.accessioned2010-04-13en_AU
dc.date.accessioned2010-04-30T05:08:26Zen_AU
dc.date.available2010-04-13en_AU
dc.date.available2010-04-30T05:08:26Zen_AU
dc.date.issued2010-01-21en_AU
dc.date.statistics2010-01-21en_AU
dc.description.abstractLayered double hydroxide (LDH) nanomaterials are currently the focus of intense scientific interest due to their potential application in drug and gene delivery research. However, the emerging field of nanotoxicology requires the development of new and more sensitive methodologies to follow the in vivo delivery kinetics as well as the persistence and bioaccumulation of the LDH carriers subsequent to delivery of the payload to the target area. Radioisotopic labeling offers very high detection sensitivity (<10−14 moles) and straightforward quantitation with respect to other labeling techniques. We have shown that incorporation of naturally occurring Co2+ and Ga3+ cations into the LDH structure has a negligible effect on the physiochemical properties of the pristine nanoparticles. Radiolabeling through dual isomorphous substitution of 57Co2+ and 67Ga3+ into the LDH structure offers the utility to accurately track and also follow the structural dissolution of these nanomaterials over a range of biologically relevant pHs. Radiolabeled-LDH kinetic release profiles in conjunction with transmission electron microscopy and X-ray diffraction studies have revealed that the bulk dissolution of LDH occurs with no preferential leaching of the 57Co2+ or 67Ga3+ metal species from the crystal structure. Furthermore, the present study clearly demonstrates how radiolabeling methodologies described here may be adapted for use in other similar clay systems and allow for the first time noninvasive imaging and monitoring of the fate of nanoparticles. © 2010, American Chemical Societyen_AU
dc.identifier.citationMusumeci, A. W., Schiller, T. L., Xu, Z. P., Minchin, R. F., Martin, D. J., & Smith, S. V. (2010). Synthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studies. Journal of Physical Chemistry C, 114(2), 734-740. doi:10.1021/jp905347xen_AU
dc.identifier.govdoc1542en_AU
dc.identifier.issn1932-7447en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleJournal of Physical Chemistry Cen_AU
dc.identifier.pagination734-740en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/jp905347xen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3154en_AU
dc.identifier.volume114en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectHydroxidesen_AU
dc.subjectSynthesisen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectDouble labellingen_AU
dc.subjectTransmission electron microscopyen_AU
dc.subjectX-ray diffractionen_AU
dc.titleSynthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studiesen_AU
dc.typeJournal Articleen_AU
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