Biodegradability of sol-gel silica microparticles for drug delivery

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dc.contributor.authorFinnie, KSen_AU
dc.contributor.authorWaller, DJen_AU
dc.contributor.authorPerret, FLen_AU
dc.contributor.authorKrause-Heuer, AMen_AU
dc.contributor.authorLin, HQen_AU
dc.contributor.authorHanna, JVen_AU
dc.contributor.authorBarbé, CJen_AU
dc.date.accessioned2010-04-06en_AU
dc.date.accessioned2010-04-30T05:08:04Zen_AU
dc.date.available2010-04-06en_AU
dc.date.available2010-04-30T05:08:04Zen_AU
dc.date.issued2009-01en_AU
dc.date.statistics2009-01en_AU
dc.description.abstractThe biodegradability of porous sol–gel silica microparticles in physiological buffers has been investigated using a USP4 flow-through dissolution tester. In the open configuration, which most closely models in-vivo conditions, the particles dissolved rapidly at pH 7.4, with a rate dependent on the surface area and media flow rate. In the closed configuration, the fastest dissolving 4 mg silica sample was almost completely dissolved in 100 mL of buffer after 36 h. The initial dissolution rates appeared relatively linear but dropped off as dissolved SiO2 concentrations approached 20–25 ppm. Addition of serum proteins acted to slow dissolution by 20–30%, suggesting a slower degradation in vivo. Silica microparticles administered for controlled release drug delivery would therefore be expected to be eliminated relatively rapidly from the body, depending on the sample size and local fluid flow conditions. © 2009, Springer. The original publication is available at www.springerlink.comen_AU
dc.identifier.citationFinnie, K. S., Waller, D. J., Perret, F. L., Krause-Heuer, A. M., Lin, H. Q., Hanna, J. V., & Barbe, G. J. (2009). Biodegradability of sol-gel silica microparticles for drug delivery. Journal of Sol-Gel Science and Technology, 49(1), 12-18. doi:10.1007/s10971-008-1847-4en_AU
dc.identifier.govdoc1519en_AU
dc.identifier.issn0928-0707en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleJournal of Sol-Gel Science and Technologyen_AU
dc.identifier.pagination12-18en_AU
dc.identifier.urihttp://dx.doi.org/10.1007/s10971-008-1847-4en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3034en_AU
dc.identifier.volume49en_AU
dc.language.isoenen_AU
dc.publisherSpringeren_AU
dc.subjectDissolutionen_AU
dc.subjectEncapsulationen_AU
dc.subjectBiodegradationen_AU
dc.subjectTherapyen_AU
dc.subjectSilicaen_AU
dc.subjectPorous materialsen_AU
dc.titleBiodegradability of sol-gel silica microparticles for drug deliveryen_AU
dc.typeJournal Articleen_AU
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