Experimental validation of proton transverse relaxivity models for superparamagnetic nanoparticle MRI contrast agents.

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dc.contributor.authorCarroll, MRJen_AU
dc.contributor.authorWoodward, RCen_AU
dc.contributor.authorHouse, MJen_AU
dc.contributor.authorTeoh, WYen_AU
dc.contributor.authorAmal, Ren_AU
dc.contributor.authorHanley, TLen_AU
dc.contributor.authorSt Pierre, TGen_AU
dc.date.accessioned2010-01-20T03:28:02Zen_AU
dc.date.accessioned2010-04-30T05:07:57Zen_AU
dc.date.available2010-01-20T03:28:02Zen_AU
dc.date.available2010-04-30T05:07:57Zen_AU
dc.date.issued2010-01-22en_AU
dc.date.statistics2010-01-22en_AU
dc.description.abstractAnalytical models of proton transverse relaxation rate enhancement by magnetic nanoparticles were tested by making measurements on model experimental systems in a field of 1.4 T. Proton relaxivities were measured for five aqueous suspensions of iron oxide (maghemite) nanoparticles with nominal mean particle sizes of 6, 8, 10, 11, and 13 nm. Proton relaxivity increased with mean particle size ranging from 13 s(-1) mM Fe-1 for the 6 nm sample, up to 254 s(-1) mM Fe-1 for the 13 nm sample. A strong correlation between the measured and predicted values of the relaxivity was observed, with the predicted values being consistently higher than the measured values. The results indicate that the models give a reasonable agreement with experimental results and hence can be used as the basis for the design of new magnetic resonance imaging contrast and labelling agents. © 2010, Institute of Physicsen_AU
dc.identifier.articlenumber35103en_AU
dc.identifier.citationCarroll, M. R. J., Woodward, R. C., House, M. J., Teoh, W. Y., Amal, R., & Hanley, T. L., et al. (2010). Experimental validation of proton transverse relaxivity models for superparamagnetic nanoparticle MRI contrast agents. Nanotechnology, 21(3), 7. doi:10.1088/0957-4484/21/3/035103en_AU
dc.identifier.govdoc1511en_AU
dc.identifier.issn0957-4484en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleNanotechnologyen_AU
dc.identifier.pagination7en_AU
dc.identifier.urihttp://dx.doi.org/10.1088/0957-4484/21/3/035103en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2710en_AU
dc.identifier.volume21en_AU
dc.language.isoenen_AU
dc.publisherInstitute of Physicsen_AU
dc.subjectMagnetic resonanceen_AU
dc.subjectTransverse momentumen_AU
dc.subjectRelaxationen_AU
dc.subjectIron oxidesen_AU
dc.subjectProtonsen_AU
dc.subjectNMR imagingen_AU
dc.titleExperimental validation of proton transverse relaxivity models for superparamagnetic nanoparticle MRI contrast agents.en_AU
dc.typeJournal Articleen_AU
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