Location of sugars in multilamellar membranes at low hydration

Simple item page
dc.contributor.authorLenné, Ten_AU
dc.contributor.authorBryant, Gen_AU
dc.contributor.authorGarvey, CJen_AU
dc.contributor.authorKelderling, Uen_AU
dc.contributor.authorKoster, KLen_AU
dc.date.accessioned2009-10-08en_AU
dc.date.accessioned2010-04-30T05:06:37Zen_AU
dc.date.available2009-10-08en_AU
dc.date.available2010-04-30T05:06:37Zen_AU
dc.date.issued2006-11-15en_AU
dc.date.statistics2006-11-15en_AU
dc.description.abstractSevere dehydration is lethal for most biological species. However, there are a number of organisms which have evolved mechanisms to avoid damage during dehydration. One of these mechanisms is the accumulation of small solutes (e.g. sugars), which have been shown to preserve membranes by inhibiting deleterious phase changes at low hydration. Specifically, sugars reduce the gel to fluid phase transition temperatures of model lipid/water mixtures. However, there is a debate about the precise mechanism, the resolution of which hinges on the location of the sugars. In excess water, it has been observed using contrast variation SANS that the sugar concentration in the excess phase is higher than in the interlamellar region [Deme and Zemb, J. Appl. Crystallog. 33 (2000) 569]. This raises two questions regarding the location of the sugars at low hydrations: first, does the system phase separate to give a sugar/water phase in equilibrium with a lipid/water/sugar lamellar region (with different sugar concentrations); and second, is the sugar in the interlamellar region uniformly distributed, or does it concentrate preferentially either in close proximity to the lipids, or towards the center of the interbilayer region. In this paper we present the preliminary results of measurements using contrast variation SANS to determine the location of sugars in lipid/water mixtures. © 2006, Elsevier Ltd.en_AU
dc.identifier.citationLenné, T., Bryant, G., Garvey, C. J., Kelderling, U., & Koster, K. L. (2006). Location of sugars in multilamellar membranes at low hydration. Paper presented at the Eighth International Conference on Neutron Scattering (ICNS 2005), "Neutrons for structure and dynamics - a new era", Sydney, Australia, 27 November to 2 December 2005. In Campbell, S. J., Cadogan, J. M., Furusaka, M., Hauser, N., & James, M. (Eds), Physica B: Condensed Matter, 385-869(Part 2), 862-864. doi:/10.1016/j.physb.2006.05.127en_AU
dc.identifier.conferenceenddate2 December 2005en_AU
dc.identifier.conferencenameEighth International Conference on Neutron Scattering ICNS 2005: 'Neutrons for structure and dynamics - a new eraen_AU
dc.identifier.conferenceplaceSydney, Australiaen_AU
dc.identifier.conferencestartdate27 November 2005en_AU
dc.identifier.editorsCampbell, S. J., Cadogan, J. M., Furusaka, M., Hauser, N., & James, M.en_AU
dc.identifier.govdoc1424en_AU
dc.identifier.issn0921-4526en_AU
dc.identifier.issuePart 2en_AU
dc.identifier.journaltitlePhysica B: Condensed Matteren_AU
dc.identifier.pagination862-864en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.physb.2006.05.127en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1972en_AU
dc.identifier.volume385-386en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectSolutesen_AU
dc.subjectDehydrationen_AU
dc.subjectMembranesen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectCryobiologyen_AU
dc.subjectSaccharidesen_AU
dc.titleLocation of sugars in multilamellar membranes at low hydrationen_AU
dc.typeConference Paperen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Conference Publications