Depressurization of an expanded solution into aqueous media for the bulk production of liposomes

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dc.contributor.authorMeure, LAen_AU
dc.contributor.authorKnott, RBen_AU
dc.contributor.authorFoster, NRen_AU
dc.contributor.authorDehghani, Fen_AU
dc.date.accessioned2009-06-16T05:42:05Zen_AU
dc.date.accessioned2010-04-30T05:06:30Zen_AU
dc.date.available2009-06-16T05:42:05Zen_AU
dc.date.available2010-04-30T05:06:30Zen_AU
dc.date.issued2009-01-06en_AU
dc.date.statistics2009-01-06en_AU
dc.description.abstractA new dense gas process for the formation of liposomes has been developed: depressurization of an expanded solution into aqueous media (DESAM). The technique provides a fast and simple process for bulk liposome formation. As an alternative to current dense gas technologies, the DESAM process reduces the pressure requirements for liposome formation. Liposomes with diameters between 50 and 200 nm were formed. For all samples produced using ethanol as the solvent, the average effective diameter ranged from 119 to 207 nm. When chloroform was used as the solvent, the average effective diameter increased to 387 nm. The residual solvent volume fraction in the liposomal product was less than 4% v/v, which is approximately one-quarter of the value reported for some other dense gas liposome formation methods. The liposomal samples were stored after formation at 5 degrees C for up to 8 months, with the average effective diameter and polydispersity increasing by only 13% and 7%, respectively, indicating high stability of the formulations. © 2009, American Chemical Societyen_AU
dc.identifier.citationMeure, L. A., Knott, R., Foster, N. R., & Dehghani, F. (2009). Depressurization of an expanded solution into aqueous media for the bulk production of liposomes. Langmuir, 25(1), 326-337. doi:10.1021/la802511aen_AU
dc.identifier.govdoc1416en_AU
dc.identifier.issn0743-7463en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleLangmuiren_AU
dc.identifier.pagination326-337en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/la802511aen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1378en_AU
dc.identifier.volume25en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectDepressurizationen_AU
dc.subjectAqueous solutionsen_AU
dc.subjectProductionen_AU
dc.subjectLiposomesen_AU
dc.subjectGasesen_AU
dc.subjectEvaporationen_AU
dc.titleDepressurization of an expanded solution into aqueous media for the bulk production of liposomesen_AU
dc.typeJournal Articleen_AU
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