Cardiac myosin-binding protein C decorates F-actin: implications for cardiac function

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dc.contributor.authorWhitten, AEen_AU
dc.contributor.authorJeffries, CMen_AU
dc.contributor.authorHarris, SPen_AU
dc.contributor.authorTrewhella, Jen_AU
dc.date.accessioned2009-09-29T06:34:33Zen_AU
dc.date.accessioned2010-04-30T05:06:13Zen_AU
dc.date.available2009-09-29T06:34:33Zen_AU
dc.date.available2010-04-30T05:06:13Zen_AU
dc.date.issued2008-11-25en_AU
dc.date.statistics2008-11-25en_AU
dc.description.abstractCardiac myosin-binding protein C (cMyBP-C) is an accessory protein of striated muscle sarcomeres that is vital for maintaining regular heart function. Its 4 N-terminal regulatory domains, C0-C1-m-C2 (C0C2), influence actin and myosin interactions, the basic contractile proteins of muscle. Using neutron contrast variation data, we have determined that C0C2 forms a repeating assembly with filamentous actin, where the C0 and C1 domains of C0C2 attach near the DNase I-binding loop and subdomain 1 of adjacent actin monomers. Direct interactions between the N terminus of cMyBP-C and actin thereby provide a mechanism to modulate the contractile cycle by affecting the regulatory state of the thin filament and its ability to interact with myosin. © 2008, National Academy of Sciencesen_AU
dc.identifier.citationWhitten, A. E., Jeffries, C. M., Harris, S. P., & Trewhella, J. (2008). Cardiac myosin-binding protein C decorates F-actin: implications for cardiac function. Proceedings of the National Academy of Sciences, 105(47), 18360-18365. doi:10.1073/pnas.0808903105en_AU
dc.identifier.govdoc1398en_AU
dc.identifier.issn0027-8424en_AU
dc.identifier.issue47en_AU
dc.identifier.journaltitleProceedings of the National Academy of Sciencesen_AU
dc.identifier.pagination18360-18365en_AU
dc.identifier.urihttp://dx.doi.org/10.1073/pnas.0808903105en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1855en_AU
dc.identifier.volume105en_AU
dc.language.isoenen_AU
dc.publisherNational Academy of Sciencesen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectMyosinen_AU
dc.subjectMusclesen_AU
dc.subjectPhosphorylationen_AU
dc.subjectHypertrophyen_AU
dc.subjectActinen_AU
dc.titleCardiac myosin-binding protein C decorates F-actin: implications for cardiac functionen_AU
dc.typeJournal Articleen_AU
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