Rapid cortico-limbic alterations in AMPA receptor densities after administration of PCP: implications for schizophrenia

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dc.contributor.authorZavitsanou, Ken_AU
dc.contributor.authorNguyen, VHen_AU
dc.contributor.authorNewell, KAen_AU
dc.contributor.authorBallantyne, Pen_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2009-06-11T03:29:02Zen_AU
dc.date.accessioned2010-04-30T05:06:00Zen_AU
dc.date.available2009-06-11T03:29:02Zen_AU
dc.date.available2010-04-30T05:06:00Zen_AU
dc.date.issued2008-10en_AU
dc.date.statistics2008-10en_AU
dc.description.abstractPhencyclidine (PCP), a non-competitive NMDA/glutamate receptor antagonist, is a psychotomimetic drug that produces a syndrome in normal humans that resembles schizophrenia. The present study investigated the mechanisms of PCP actions by examining the density of glutamate and muscarinic receptors in the rat brain 4 h after a single injection of PCP. We used receptor autoradiography and [H-3]MK801, [H-3]AMPA, [H-3]pirenzepine and [H-3]AFDX384 to target glutamate NMDA, glutamate AMPA and muscarinic M1 and M2 receptors, respectively. The major outcome from the present study was an overall decrease in levels of the glutamate AMPA receptor density (F= 14.5, d.f. = 1, p < 0.001) in the PCP treated rats. More specifically, PCP-treated animals displayed decreased AMPA receptor density in hippocampus CA1 (-16%), hippocampus CA2 (-25%), dentate gyrus (-27%), parietal cortex layers III-VI (-19%), central nucleus of the amygdala (-40%), and basolateral amygdala (-19%). Other brain regions examined were unaffected. PCP administration did not significantly affect glutamate NMDA, muscarinic M1 and M2 receptor density. The present study demonstrates the limbic system as the anatomical locus of alterations in AMPA receptor density after acute administration of PCP and may have implications for models of schizophrenia that focus on glutamatergic dysfunction in limbic cortical regions. © 2008, Elsevier Ltd.en_AU
dc.identifier.citationZavitsanou, K., Nguyen, V., Newell, K., Ballantyne, P., & Huang, X. F. (2008). Rapid cortico-limbic alterations in AMPA receptor densities after administration of PCP: implications for schizophrenia. Journal of Chemical Neuroanatomy, 36(2), 71-76. doi:10.1016/j.jchemneu.2008.06.004en_AU
dc.identifier.govdoc1386en_AU
dc.identifier.issn0891-0618en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleJournal of Chemical Neuroanatomyen_AU
dc.identifier.pagination71-76en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.jchemneu.2008.06.004en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1331en_AU
dc.identifier.volume36en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectReceptorsen_AU
dc.subjectBrainen_AU
dc.subjectAutoradiographyen_AU
dc.subjectRatsen_AU
dc.subjectDensityen_AU
dc.subjectHippocampusen_AU
dc.titleRapid cortico-limbic alterations in AMPA receptor densities after administration of PCP: implications for schizophreniaen_AU
dc.typeJournal Articleen_AU
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