Molecular level and microstructural characterisation of thermally sensitive chitosan hydrogels

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dc.contributor.authorCrompton, KEen_AU
dc.contributor.authorForsythe, JSen_AU
dc.contributor.authorHorne, MKen_AU
dc.contributor.authorFinkelstein, DIen_AU
dc.contributor.authorKnott, RBen_AU
dc.date.accessioned2010-01-21T04:45:47Zen_AU
dc.date.accessioned2010-04-30T05:05:14Zen_AU
dc.date.available2010-01-21T04:45:47Zen_AU
dc.date.available2010-04-30T05:05:14Zen_AU
dc.date.issued2009-09-15en_AU
dc.date.statistics2009-09-15en_AU
dc.description.abstractChitosan-glycerophosphate (GP) is a physiological pH solution at room temperature which forms a physical hydrogel upon heating to 37 degrees C. The hydrogel is suitable for biomedical applications and in particular as a biodegradable scaffold for tissue engineering. Since the structure of the hydrogel is critical to cell-material interactions, small angle neutron scattering (SANS) and ultra SANS (USANS) were used to examine the molecular conformation of chitosan chains and the larger scale microstructure. On the nanoscale, the hydrogel is described in terms of a static component (characteristic length, Xi) which accounts for the physical cross-links, and a dynamic component (correlation length, xi) which accounts for solution-like properties. Over the range 0.25-1.5 w/v% chitosan concentration the molecular structure is dependent on concentration with the characteristic length decreasing from similar to 450 angstrom to similar to 300 angstrom, and the correlation length increasing from similar to 110 angstrom to similar to 130 angstrom. The chitosan chains were arranged at a larger scale into polymer-rich aggregates of 1-2 mu m diameter which decreased in size as the chitosan concentration increased. Such structural information is important for tailoring the hydrogel for specific applications. © 2009, Royal Society of Chemistryen_AU
dc.identifier.citationCrompton, K. E., Forsythe, J. S., Horne, M. K., Finkelstein, D. I., & Knott, R. B. (2009). Molecular level and microstructural characterisation of thermally sensitive chitosan hydrogels. Soft Matter, 5(23), 4704-4711. doi:10.1039/b907593cen_AU
dc.identifier.govdoc1342en_AU
dc.identifier.issn1744-683Xen_AU
dc.identifier.issue23en_AU
dc.identifier.journaltitleSoft Matteren_AU
dc.identifier.pagination4704-4711en_AU
dc.identifier.urihttp://dx.doi.org/10.1039/b907593cen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2730en_AU
dc.identifier.volume5en_AU
dc.language.isoenen_AU
dc.publisherRoyal Society of Chemistryen_AU
dc.subjectHydrogelsen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectEncapsulationen_AU
dc.subjectMolecular structureen_AU
dc.subjectCorrelationsen_AU
dc.subjectSensitivityen_AU
dc.titleMolecular level and microstructural characterisation of thermally sensitive chitosan hydrogelsen_AU
dc.typeJournal Articleen_AU
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