Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics.

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dc.contributor.authorRizwan, SBen_AU
dc.contributor.authorHanley, TLen_AU
dc.contributor.authorBoyd, BJen_AU
dc.contributor.authorRades, Ten_AU
dc.contributor.authorHook, Sen_AU
dc.date.accessioned2009-11-23T02:43:06Zen_AU
dc.date.accessioned2010-04-30T05:05:11Zen_AU
dc.date.available2009-11-23T02:43:06Zen_AU
dc.date.available2010-04-30T05:05:11Zen_AU
dc.date.issued2009-11en_AU
dc.date.statistics2009-11en_AU
dc.description.abstractSwelling and phase behaviour of phytantriol and glyceryl monooleate (GMO) matrices with varying water loadings were investigated. Release of a model protein, FITC-Ova was subsequently examined. Polarised light microscopy and small angle X-ray scattering analysis showed that the addition of FITC-Ova only altered the liquid crystalline structure of phytantriol matrices at low water loadings, and that postrelease study, the phase structure of matrices at both low and high loading reflected that of the binary system. Addition of FITC-Ova to GMO matrices also altered the liquid crystalline structure when compared to the respective binary system at low but not at high loading. All samples analysed after the release study had transformed to the reverse hexagonal phase (H-II). Swelling studies revealed a faster and more extensive swelling of GMO when compared to phytantriol. Release of FITC-Ova from phytantriol matrices was faster and occurred to a greater extent most likely due to the conversion of GMO matrices into the H-II phase. No effect on release as a function of initial water content was observed for either lipid. We have confirmed that phytantriol based liquid crystalline matrices can sustain the release of a hydrophilic protein, suggesting its suitability as a potential sustained antigen-delivery system. © 2009, Wiley-Blackwell.en_AU
dc.identifier.citationRizwan, S. B., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2009). Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics. Journal of Pharmaceutical Sciences, 98(11), 4191-4204. doi:10.1002/jps.21724en_AU
dc.identifier.govdoc1338en_AU
dc.identifier.issn0022-3549en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitleJournal of Pharmaceutical Sciencesen_AU
dc.identifier.pagination4191-4204en_AU
dc.identifier.urihttp://dx.doi.org/10.1002/jps.21724en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2436en_AU
dc.identifier.volume98en_AU
dc.language.isoenen_AU
dc.publisherWiley-Blackwellen_AU
dc.subjectDiffusionen_AU
dc.subjectProteinsen_AU
dc.subjectLipidsen_AU
dc.subjectKineticsen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectSwellingen_AU
dc.titleLiquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics.en_AU
dc.typeJournal Articleen_AU
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