HU210-induced downregulation in cannabinoid CB1 receptor binding strongly correlates with body weight loss in the adult rat.

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dc.contributor.authorDalton, VSen_AU
dc.contributor.authorWang, HQen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2009-08-20T06:11:06Zen_AU
dc.date.accessioned2010-04-30T05:04:48Zen_AU
dc.date.available2009-08-20T06:11:06Zen_AU
dc.date.available2010-04-30T05:04:48Zen_AU
dc.date.issued2009-07en_AU
dc.date.statistics2009-07en_AU
dc.description.abstractIn vitro autoradiography was used to examine changes in cannabinoid CB1 receptors (targeted with [H-3] CP55,940) in rats treated with the potent cannabinoid agonist HU210. Animals were administered with HU210 (25, 50, 100 mu g/kg) for 4 or 14 days or received a single 100 mu g/kg injection of HU210 and sacrificed 24 h later. The acute dose resulted in a decrease in binding in the caudate putamen and hippocampus. A dose dependent, region-specific reduction (P < 0.0001) in [H-3] CP55,940 binding was seen in all brain regions examined after 4 and 14 days treatment. A decrease in body weight was recorded during the first 4 days of treatment but after this animals began to gain weight. Correlations (0.865 < r < 0.659, P < 0.0001) between body weight on day four and CB1 receptor binding were found in all brain regions examined suggesting that downregulation of CB1 receptors may contribute to the induction of tolerance to body weight loss induced by HU210. © 2009, Springer.en_AU
dc.identifier.citationDalton, V. S., Wang, H. Q., & Zavitsanou, K. (2009). HU210-induced downregulation in cannabinoid CB1 receptor binding strongly correlates with body weight loss in the adult rat. Neurochemical Research, 34(7), 1343-1353. doi:10.1007/s11064-009-9914-yen_AU
dc.identifier.govdoc1313en_AU
dc.identifier.issn0364-3190en_AU
dc.identifier.issue7en_AU
dc.identifier.journaltitleNeurochemical Researchen_AU
dc.identifier.pagination1343-1353en_AU
dc.identifier.urihttp://dx.doi.org/10.1007/s11064-009-9914-yen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1695en_AU
dc.identifier.volume34en_AU
dc.language.isoenen_AU
dc.publisherSpringeren_AU
dc.subjectAutoradiographyen_AU
dc.subjectMessenger-RNAen_AU
dc.subjectRatsen_AU
dc.subjectWeighten_AU
dc.subjectReceptorsen_AU
dc.subjectBrainen_AU
dc.titleHU210-induced downregulation in cannabinoid CB1 receptor binding strongly correlates with body weight loss in the adult rat.en_AU
dc.typeJournal Articleen_AU
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