PAMAM dendrimers as potential agents against fibrillation of α-synuclein, a parkinson's disease-related protein.

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dc.contributor.authorRekas, Aen_AU
dc.contributor.authorLo, Ven_AU
dc.contributor.authorGadd, GEen_AU
dc.contributor.authorCappai, Ren_AU
dc.contributor.authorYun, SLen_AU
dc.date.accessioned2009-09-29T05:43:05Zen_AU
dc.date.accessioned2010-04-30T05:04:21Zen_AU
dc.date.available2009-09-29T05:43:05Zen_AU
dc.date.available2010-04-30T05:04:21Zen_AU
dc.date.issued2009-03-10en_AU
dc.date.statistics2009-03-10en_AU
dc.description.abstractThe effect of PAMAM dendrimers (generations G3, G4 and G5) on the fibrillation of α-synuclein was examined by fluorescence and CD spectroscopy, TEM and SANS. PAMAM dendrimers inhibited fibrillation of α-synuclein and this effect increased both with generation number and PAMAM concentration. SANS showed structural changes in the formed aggregates of α-synuclein - from cylindrical to dense three-dimensional ones-as the PAMAM concentration increased, on account of the inhibitory effect. PAMAM also effectively promoted the breaking down of pre-existing fibrils of α-synuclein. In both processes-that is, inhibition and disassociation of fibrils-PAMAM redirected α-synuclein to an amorphous aggregation pathway. © 2009, Wiley-VCH Verlag Berlinen_AU
dc.identifier.citationRekas, A., Lo, V., Gadd, G. E., Cappai, R., & Yun, S. L. (2009). PAMAM dendrimers as potential agents against fibrillation of α-synuclein, a parkinson's disease-related protein. Macromolecular Bioscience, 9(3), 230-238. doi:10.1002/mabi.200800242en_AU
dc.identifier.govdoc1282en_AU
dc.identifier.issn1616-5187en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleMacromolecular Bioscienceen_AU
dc.identifier.pagination230-238en_AU
dc.identifier.urihttp://dx.doi.org/10.1002/mabi.200800242en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1851en_AU
dc.identifier.volume9en_AU
dc.language.isoenen_AU
dc.publisherWiley-VCH Verlag Berlinen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectAgglomerationen_AU
dc.subjectPeptidesen_AU
dc.subjectFluorescenceen_AU
dc.subjectAmorphous stateen_AU
dc.subjectTransmission electron microscopyen_AU
dc.titlePAMAM dendrimers as potential agents against fibrillation of α-synuclein, a parkinson's disease-related protein.en_AU
dc.typeJournal Articleen_AU
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