Stimuli responsive liquid crystals provide 'on-demand' drug delivery in vitro and in vivo

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dc.contributor.authorFong, WKen_AU
dc.contributor.authorHanley, TLen_AU
dc.contributor.authorBoyd, BJen_AU
dc.date.accessioned2009-06-16T03:51:06Zen_AU
dc.date.accessioned2010-04-30T05:03:57Zen_AU
dc.date.available2009-06-16T03:51:06Zen_AU
dc.date.available2010-04-30T05:03:57Zen_AU
dc.date.issued2009-05-05en_AU
dc.date.statistics2009-05-05en_AU
dc.description.abstractLipid-based liquid crystalline materials have been proposed as controlled drug delivery systems. Differences in liquid crystal nanostructure have previously been shown to change drug diffusion and hence release, however there has been little progress towards the use of in situ changes to nanostructure to control drug release. In this study, phytantriol and glyceryl monooleate-based bicontinuous cubic (Q(2)) and inverse hexagonal (H-2) nanostructures have been designed to allow change to the nanostructure in response to external change in temperature, with a view to controlling drug release rates in vivo. Changes to nanostructure with temperature were confirmed by crossed polarised optical microscopy and small angle X-ray scattering. Phytantriol containing 3% (w/w) vitamin E acetate provided the necessary phase transition behaviour to progress this system to in vitro release and in vivo proof of concept studies. Using glucose as a model hydrophilic drug, drug diffusion was shown to be reversible on switching between the H-2 and Q(2) nanostructures at temperatures above and below physiological temperature respectively. An in vivo proof of concept study in rats showed that after subcutaneous administration of these materials, the changes in nanostructure induced by application of a heat or cool pack at the injection site stimulated changes in drug release from the matrix anticipated from in vitro release behaviour, thereby demonstrating the potential utility of these systems as 'on demand' drug release delivery vehicles. © 2009, Elsevier Ltd.en_AU
dc.identifier.citationFong, W. K., Hanley, T., & Boyd, B. J. (2009). Stimuli responsive liquid crystals provide 'on-demand' drug delivery in vitro and in vivo. Journal of Controlled Release, 135(3), 218-226. doi:10.1016/j.jconrel.2009.01.009en_AU
dc.identifier.govdoc1259en_AU
dc.identifier.issn0168-3659en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleJournal of Controlled Releaseen_AU
dc.identifier.pagination218-226en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.jconrel.2009.01.009en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1372en_AU
dc.identifier.volume135en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectStimulien_AU
dc.subjectLiquid crystalsen_AU
dc.subjectIn vitroen_AU
dc.subjectIn vivoen_AU
dc.subjectDiffusionen_AU
dc.subjectDeliveryen_AU
dc.titleStimuli responsive liquid crystals provide 'on-demand' drug delivery in vitro and in vivoen_AU
dc.typeJournal Articleen_AU
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