MULCh: modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies.

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dc.contributor.authorWhitten, AEen_AU
dc.contributor.authorCa, SZen_AU
dc.contributor.authorTrewhella, Jen_AU
dc.date.accessioned2008-04-18T05:38:39Zen_AU
dc.date.accessioned2010-04-30T05:03:18Zen_AU
dc.date.available2008-04-18T05:38:39Zen_AU
dc.date.available2010-04-30T05:03:18Zen_AU
dc.date.issued2008-02en_AU
dc.date.statistics2008-02en_AU
dc.description.abstractSmall-angle neutron scattering with contrast variation can fill important gaps in our understanding of biomolecular assemblies, providing constraints that can aid in the construction of molecular models and in subsequent model refinements. This paper describes the implementation of simple tools for analysing neutron contrast variation data, accessible via a user-friendly web-based interface (http://www.mmb.usyd.edu.au/NCVWeb/). There are three modules accessible from the website to analyse neutron contrast variation data from bimolecular complexes. The first module, Contrast, computes neutron contrasts of each component of the complex required by the other two modules; the second module, R, analyses the contrast dependence of the radii of gyration to yield information relating to the size and disposition of each component in the complex; and the third, Compost, decomposes the contrast variation series into composite scattering functions, which contain information regarding the shape of each component of the complex, and their orientation with respect to each other. © 2008, Wiley-Blackwell.en_AU
dc.identifier.citationWhitten, A. E., Ca, S. Z., & Trewhella, J. (2008). MULCh: modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies. Journal of Applied Crystallography, 41, 222-226. doi:10.1107/S0021889807055136en_AU
dc.identifier.govdoc1213en_AU
dc.identifier.issn0021-8898en_AU
dc.identifier.journaltitleJournal of Applied Crystallographyen_AU
dc.identifier.pagination222-226en_AU
dc.identifier.urihttp://dx.doi.org/10.1107/S0021889807055136en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1079en_AU
dc.identifier.volume41en_AU
dc.language.isoenen_AU
dc.publisherWiley-Blackwellen_AU
dc.subjectProteinsen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectPhosphotransferasesen_AU
dc.subjectComplexesen_AU
dc.subjectStowingen_AU
dc.subjectSimulationen_AU
dc.titleMULCh: modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies.en_AU
dc.typeJournal Articleen_AU
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