DLC coatings: effects of physical and chemical properties on biological response

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dc.contributor.authorMa, WJen_AU
dc.contributor.authorRuys, AJen_AU
dc.contributor.authorMason, RSen_AU
dc.contributor.authorMartin, PJen_AU
dc.contributor.authorBendavid, Aen_AU
dc.contributor.authorLiu, ZWen_AU
dc.contributor.authorZreiqat, Hen_AU
dc.contributor.authorIonescu, Men_AU
dc.date.accessioned2008-04-23T01:55:54Zen_AU
dc.date.accessioned2010-04-30T05:02:25Zen_AU
dc.date.available2008-04-23T01:55:54Zen_AU
dc.date.available2010-04-30T05:02:25Zen_AU
dc.date.issued2007-03en_AU
dc.date.statistics2007-03en_AU
dc.description.abstractRecent trials on diamond-like carbon (DLC) coated medical devices have indicated promise for blood interfacing applications. The literature is sparse regarding structural and compositional effects of DLC on cellular response. An important goal in optimizing blood-interfacing implants is minimal macrophage attachment, and maximal albumin:fibrinogen adsorption ratio. DLC coatings deposited by PACVD and FAD, were analysed with respect to sp(3) content (EELS), hydrogen content (ERDA), surface composition (XPS), surface roughness (AFM), surface energy, albumin: fibrinogen adsorption ratio, and macrophage viability and attachment. We found that increasing surface roughness and surface energy enhanced the macrophage viability and the albumin: fibrinogen adsorption ratio. We also found that the higher the hydrogen content for a-C:Hs deposited by PACVD, the lower the albumin:fibrinogen adsorption ratio, and macrophage attachment. This suggests that hydrogen content may be an important factor for influencing the biological response of DLC surfaces. Macrophage cells spread well on all DLC surfaces, and the surface results indicated the non-toxic nature of the surfaces on the cells at the time points tested. © 2007, Elsevier Ltd.en_AU
dc.identifier.citationMa, W. J., Ruys, A. J., Mason, R. S., Martin, P. J., Bendavid, A., Liu, Z. W., Zreiqat, H., & Ionescu, M. (2007). DLC coatings: effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628. doi:10.1016/j.biomaterials.2006.12.010en_AU
dc.identifier.govdoc1149en_AU
dc.identifier.issn0142-9612en_AU
dc.identifier.issue9en_AU
dc.identifier.journaltitleBiomaterialsen_AU
dc.identifier.pagination1620-1628en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.biomaterials.2006.12.010en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1105en_AU
dc.identifier.volume28en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectCoatingsen_AU
dc.subjectBiological adaptationen_AU
dc.subjectChemical propertiesen_AU
dc.subjectPhysical propertiesen_AU
dc.subjectCarbonen_AU
dc.subjectBlooden_AU
dc.titleDLC coatings: effects of physical and chemical properties on biological responseen_AU
dc.typeJournal Articleen_AU
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