Imaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody.

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dc.contributor.authorDearling, JLJen_AU
dc.contributor.authorVoss, SDen_AU
dc.contributor.authorDunning, Pen_AU
dc.contributor.authorSnay, Een_AU
dc.contributor.authorFahey, Fen_AU
dc.contributor.authorSmith, SVen_AU
dc.contributor.authorHuston, JSen_AU
dc.contributor.authorMeares, CFen_AU
dc.contributor.authorTreves, STen_AU
dc.contributor.authorPackard, ABen_AU
dc.date.accessioned2011-02-28T05:07:37Zen_AU
dc.date.available2011-02-28T05:07:37Zen_AU
dc.date.issued2011-01-01en_AU
dc.date.statistics2011-01-01en_AU
dc.description.abstractUse of copper radioisotopes in antibody radiolabeling is challenged by reported loss of the radionuclide from the bifunctional chelator used to label the protein. The objective of this study was to investigate the relationship between the thermodynamic stability of the 64Cu-complexes of five commonly used bifunctional chelators (BFCs) and the biodistribution of an antibody labeled with 64Cu using these chelators in tumor-bearing mice. © 2011, Elsevieren_AU
dc.identifier.citationDearling, J. L. J., Voss, S. D., Dunning, P., Snay, E., Fahey, F., Smith, S. V., Huston, J. S., Meares, C. F., Treves, S. T., Packard, A. B. (2011). Imaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody. Nuclear Medicine and Biology, 38(1), 29-38. doi:10.1016/j.nucmedbio.2010.07.003en_AU
dc.identifier.govdoc3236en_AU
dc.identifier.issn0969-8051en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleNuclear Medicine and Biologyen_AU
dc.identifier.pagination29-38en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.nucmedbio.2010.07.003en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3099en_AU
dc.identifier.volume38en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectMiceen_AU
dc.subjectCopper 64en_AU
dc.subjectLabellingen_AU
dc.subjectThermodynamicsen_AU
dc.subjectRadioisotopesen_AU
dc.subjectNeoplasmsen_AU
dc.titleImaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody.en_AU
dc.typeJournal Articleen_AU
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