Radiotracer studies of the antitumor metallocene molybdocene dichloride with biomolecules

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dc.contributor.authorCampbell, KSen_AU
dc.contributor.authorDillon, CTen_AU
dc.contributor.authorSmith, SVen_AU
dc.contributor.authorHarding, MMen_AU
dc.date.accessioned2010-10-21T04:18:04Zen_AU
dc.date.available2010-10-21T04:18:04Zen_AU
dc.date.issued2007-01-22en_AU
dc.date.statistics2007-01-22en_AU
dc.description.abstractNeutron irradiation of Cp2MoCl2 for 24 h afforded the radiotracer Cp299MoCl2 which was characterised by UV–Vis spectroscopy and thin layer chromatography. Binding experiments with the thiol containing protein human serum albumin (HSA) or calf thymus DNA, were monitored for 99Mo using a gamma counter. Under the conditions investigated, molar ratios of binding of 0.2:1 (Cp2MoCl2:DNA) and 9.4:1 (Cp2MoCl2:HSA) were calculated. The results are consistent with in vitro coordination studies that have shown strong preferential interaction of Cp2MoCl2 with thiols versus other donor sites in biomolecules including DNA. © 2007, Elsevier Ltd.en_AU
dc.identifier.citationCampbell, K. S., Dillon, C. T., Smith, S. V., & Harding, M. M. (2007). Radiotracer studies of the antitumor metallocene molybdocene dichloride with biomolecules. Polyhedron, 26(2), 456-459. doi:10.1016/j.poly.2006.07.004en_AU
dc.identifier.govdoc2885en_AU
dc.identifier.issn0277-5387en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitlePolyhedronen_AU
dc.identifier.pagination456-459en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.poly.2006.07.004en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2724en_AU
dc.identifier.volume26en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectIrradiationen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectTracer techniquesen_AU
dc.subjectThin-layer chromatographyen_AU
dc.subjectSpectroscopyen_AU
dc.subjectBlood serumen_AU
dc.titleRadiotracer studies of the antitumor metallocene molybdocene dichloride with biomoleculesen_AU
dc.typeJournal Articleen_AU
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