Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water soluble drugs I. Phase behaviour in physiologically-relevant media

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dc.contributor.authorNguyen, THen_AU
dc.contributor.authorHanley, TLen_AU
dc.contributor.authorPorter, CJHen_AU
dc.contributor.authorLarson, Ien_AU
dc.contributor.authorBoyd, BJen_AU
dc.date.accessioned2010-08-04T05:39:53Zen_AU
dc.date.available2010-08-04T05:39:53Zen_AU
dc.date.issued2010-07en_AU
dc.date.statistics2010-07en_AU
dc.description.abstractObjectives: the potential utility of liquid crystalline lipid-based formulations in oral drug delivery is expected to depend critically on their structure formation and stability in gastrointestinal fluids. The phase behaviour of lipid-based liquid crystals formed by phytantriol and glyceryl monooleate, known to form a bicontinuous cubic phase in excess water, was therefore assessed in physiologically-relevant simulated gastrointestinal media. Methods: fixed composition phase studies, crossed polarised light microscopy (CPLM) and small angle X-ray scattering (SAXS) were used to determine the phase structures formed in phosphate-buffered saline, simulated gastric and intestinal fluids in the presence of model poorly water soluble drugs cinnarizine, diazepam and vitamin E acetate. Key findings: the phase behaviour of phytantriol in phosphate-buffered saline was very similar to that in water. Increasing concentrations of bile components (bile salts and phospholipids) caused an increase in the lattice parameter of the cubic phase structure for both lipids. Incorporation of cinnarizine and diazepam did not influence the phase behaviour of the phytantriol- or glyceryl monooleate-based systems at physiological temperatures; however, an inverse hexagonal phase formed on incorporation of vitamin E acetate. Conclusions: Phytantriol and glyceryl monooleate have the potential to form stable cubic phase liquid crystalline delivery systems in the gastrointestinal tract. In-vivo studies to assess their sustained-release behaviour are warranted. © 2010, Wiley-Blackwell.en_AU
dc.identifier.citationNguyen, T. -H., Hanley, T., Porter, C. J. H., Larson, I., & Boyd, B. J. (2010). Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water soluble drugs I. Phase behaviour in physiologically-relevant media. Journal of Pharmacy and Pharmacology, 62(7), 844-855. doi:10.1211/jpp.62.07.0005en_AU
dc.identifier.govdoc2162en_AU
dc.identifier.issn0022-3573en_AU
dc.identifier.issue7en_AU
dc.identifier.journaltitleJournal of Pharmacy and Pharmacologyen_AU
dc.identifier.pagination844-855en_AU
dc.identifier.urihttps://doi.org/10.1211/jpp.62.07.0005en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2022en_AU
dc.identifier.volume62en_AU
dc.language.isoenen_AU
dc.publisherWiley-Blackwellen_AU
dc.subjectLiquid crystalsen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectGastrointestinal tracten_AU
dc.subjectBileen_AU
dc.subjectSolubilityen_AU
dc.subjectOral administrationen_AU
dc.titlePhytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water soluble drugs I. Phase behaviour in physiologically-relevant mediaen_AU
dc.typeJournal Articleen_AU
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