Receptor changes in brain tissue of rats treated as neonates with capsaicin

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dc.contributor.authorZavitsanou, Ken_AU
dc.contributor.authorDalton, VSen_AU
dc.contributor.authorWang, HQen_AU
dc.contributor.authorNewson, Pen_AU
dc.contributor.authorChahl, LAen_AU
dc.date.accessioned2010-07-02T05:35:17Zen_AU
dc.date.available2010-07-02T05:35:17Zen_AU
dc.date.issued2010-07en_AU
dc.date.statistics2010-07en_AU
dc.description.abstractCapsaicin, the hot chemical in chillies, administered to neonatal rats, causes destruction of polymodal nociceptive primary afferent neurons by acting on TRPV1 receptors causing intrinsic somatosensory deprivation. Although the effects of neonatal capsaicin treatment in the periphery have been extensively investigated, less is known about the brain networks to which the capsaicin sensory neurons are relayed. In the present study the effect of neonatal capsaicin treatment on brain receptors that have been shown to interact with TRPV1 was examined. Wistar rats were treated on neonatal day 2 with capsaicin and at 15–16 weeks of age, brains were processed to measure levels of muscarinic M1/M2 and M2/M4, serotonin 5HT2A, cannabinoid CB1, dopamine D1, D2 receptors and dopamine transporter. Overall increases in levels of muscarinic M1/M4 (F = 8.219, df = 1, p = 0.005), muscarinic M2/M4 (F = 99.759, df = 1, p < 0.0001), serotonin 5HT2A (F = 28.892, df = 1, p < 0.0001), dopamine D1 (F = 8.726, df = 1, p = 0.008) and cannabinoid CB1 (F = 25.084, df = 1, p < 0.0001) receptors were found in the brains of capsaicin-treated rats, although significant regional changes occurred only in muscarinic M2/M4 and serotonin 5HT2A receptors. The results of the present study suggest that neonatal intrinsic somatosensory deprivation may have a significant impact on substrates at the central nervous system that manifest as changes in central cholinergic, monaminergic and cannabinoid systems in the adult animal. © 2010, Elsevier Ltd.en_AU
dc.identifier.citationZavitsanou, K., Dalton, V. S., Wang, H. Q., Newson, P., & Chahl, L. A. (2010). Receptor changes in brain tissue of rats treated as neonates with capsaicin. Journal of Chemical Neuroanatomy, 39(4), 248-255. doi:10.1016/j.jchemneu.2010.01.004en_AU
dc.identifier.govdoc1821en_AU
dc.identifier.issn0891-0618en_AU
dc.identifier.issue4en_AU
dc.identifier.journaltitleJournal of Chemical Neuroanatomyen_AU
dc.identifier.pagination248-255en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.jchemneu.2010.01.004en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1723en_AU
dc.identifier.volume39en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectSerotoninen_AU
dc.subjectDopamineen_AU
dc.subjectRatsen_AU
dc.subjectBrainen_AU
dc.subjectReceptorsen_AU
dc.subjectNeonatesen_AU
dc.titleReceptor changes in brain tissue of rats treated as neonates with capsaicinen_AU
dc.typeJournal Articleen_AU
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