Nonequilibrium effects in self-assembled mesophase materials: unexpected supercooling effects for cubosomes and hexosomes

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dc.contributor.authorDong, YDen_AU
dc.contributor.authorTilley, AJen_AU
dc.contributor.authorLarson, Ien_AU
dc.contributor.authorLawrence, MJen_AU
dc.contributor.authorAmenitsch, Hen_AU
dc.contributor.authorRappolt, Men_AU
dc.contributor.authorHanley, TLen_AU
dc.contributor.authorBoyd, BJen_AU
dc.date.accessioned2010-06-15T05:29:01Zen_AU
dc.date.available2010-06-15T05:29:01Zen_AU
dc.date.issued2010-06-01en_AU
dc.date.statistics2010-06-01en_AU
dc.description.abstractPolar lipids often exhibit equilibrium liquid crystalline structures in excess water, such as the bicontinuous cubic phases (QII) at low temperatures and inverse hexagonal phase (HII) at higher temperatures. In this study, the equilibrium and nonequilibrium phase behavior of glyceryl monooleate (GMO) and phytantriol (PHYT) systems in excess water were investigated using both continuous heating and cooling cycles, and rapid temperature changes. Evolution of the phase structure was followed using small-angle X-ray scattering (SAXS). During cooling, not only was supercooling of the liquid crystalline systems by up to 25 °C observed, but evidence for nonequilibrium phase structures (not present on heating; such as the gyroid cubic phase only present at low water content in equilibrium) was also apparent. The nonequilibrium phases were surprisingly stable, with return to equilibrium structure for dispersed submicrometer sized particle systems taking more than 13 h in some cases. Inhibition of phase nucleation was the key to greater supercooling effects observed for the dispersed particles compared to the bulk systems. These findings highlight the need for continued study into the nonequilibrium phase structures for these types of systems, as this may influence performance in applications such as drug delivery. © 2010, American Chemical Societyen_AU
dc.identifier.citationDong, Y. D., Tilley, A. J., Larson, I., Lawrence, M. J., Amenitsch, H., Rappolt, M., Hanley, T. L. & Boyd, B. (2010). Nonequilibrium effects in self-assembled mesophase materials: unexpected supercooling effects for cubosomes and hexosomes. Langmuir, 26(11), 9000-9010. doi:10.1021/la904803cen_AU
dc.identifier.govdoc1761en_AU
dc.identifier.issn0743-7463en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitleLangmuiren_AU
dc.identifier.pagination9000-9010en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/la904803cen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1714en_AU
dc.identifier.volume26en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectLipidsen_AU
dc.subjectCrystal structureen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectHexagonal latticesen_AU
dc.subjectDeliveryen_AU
dc.subjectLiquid crystalsen_AU
dc.titleNonequilibrium effects in self-assembled mesophase materials: unexpected supercooling effects for cubosomes and hexosomesen_AU
dc.typeJournal Articleen_AU
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