Application of polyethylene glycol to promote cellular biocompatibility of polyhydroxybutyrate films

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dc.contributor.authorChan, RTHen_AU
dc.contributor.authorMarçal, Hen_AU
dc.contributor.authorRussell, RAen_AU
dc.contributor.authorHolden, PJen_AU
dc.contributor.authorFoster, LJRen_AU
dc.date.accessioned2012-02-22T01:19:12Zen_AU
dc.date.available2012-02-22T01:19:12Zen_AU
dc.date.issued2011-08-22en_AU
dc.date.statistics2012-02-22en_AU
dc.description.abstractPolyhydroxybutyrate (PHB) is a biomaterial with potential for applications in biomedical and tissue engineering; however, its brittle nature and high crystallinity limit its potential. Blending PHB with a variety of PEGs produced natural-synthetic composite films composed of FDA-approved polymers with significant reductions in crystallinity, from 70.1% for PHB films to 41.5% for its composite with a 30% (w/w) loading of PEG2000. Blending also enabled manipulation of the material properties, increasing film flexibility with an extension to break of 2.49±1.01% for PHB films and 8.32±1.06% for films containing 30% (w/w) PEG106. Significant changes in the film surface properties, as measured by porosity, contact angles, and water uptake, were also determined as a consequence of the blending process, and these supported greater adhesion and proliferation of neural-associated olfactory ensheathing cells (OECs). A growth rate of 7.2×105 cells per day for PHB films with 30% (w/w) PEG2000 loading compared to 2.5×105 for PHB films was observed. Furthermore, while cytotoxicity of the films as measured by lactate dehydrogenase release was unaffected, biocompatibility, as measured by mitochondrial activity, was found to increase. It is anticipated that fine control of PEG composition in PHB-based composite biomaterials can be utilised to support their applications in medicinal and tissue engineering applications. Copyright © 2011 Rodman T. H. Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_AU
dc.identifier.articlenumber473045en_AU
dc.identifier.citationChan, R. T. H., Marçal, H., Russell, R. A., Holden, P. J., & Foster, L. J. R. (2011). Application of polyethylene glycol to promote cellular biocompatibility of polyhydroxybutyrate films. International Journal of Polymer Science, 2011(2011), Art. No. 473045. doi:10.1155/2011/473045en_AU
dc.identifier.govdoc3814en_AU
dc.identifier.issn1687-9430en_AU
dc.identifier.issn1687-9422en_AU
dc.identifier.journaltitleInternational Journal of Polymer Scienceen_AU
dc.identifier.urihttp://dx.doi.org/10.1155/2011/473045en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4059en_AU
dc.identifier.volume2011en_AU
dc.language.isoenen_AU
dc.publisherHindawi Publishing Corporationen_AU
dc.subjectPolyethylenesen_AU
dc.subjectGlycolsen_AU
dc.subjectFilmsen_AU
dc.subjectPolymersen_AU
dc.subjectLactatesen_AU
dc.subjectMedicinal plantsen_AU
dc.titleApplication of polyethylene glycol to promote cellular biocompatibility of polyhydroxybutyrate filmsen_AU
dc.typeJournal Articleen_AU
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