Investigation of the mouse cerebellum using STIM and mu-PIXE spectrometric and FTIR spectroscopic mapping and imaging

Simple item page
dc.contributor.authorHackett, MJen_AU
dc.contributor.authorSiegele, Ren_AU
dc.contributor.authorEl-Assaad, Fen_AU
dc.contributor.authorMcQuillan, JAen_AU
dc.contributor.authorAitken, JBen_AU
dc.contributor.authorCarter, EAen_AU
dc.contributor.authorGrau, GEen_AU
dc.contributor.authorHunt, NHen_AU
dc.contributor.authorCohen, DDen_AU
dc.contributor.authorLay, PAen_AU
dc.date.accessioned2012-04-18T04:40:19Zen_AU
dc.date.available2012-04-18T04:40:19Zen_AU
dc.date.issued2011-10-15en_AU
dc.date.statistics2012-04-18en_AU
dc.description.abstractThe cerebral biochemistry associated with the development of many neurological diseases remains poorly understood. In particular, incomplete understanding of the mechanisms through which vascular inflammation manifests in tissue damage and altered brain function is a significant hindrance to the development of improved patient therapies. To this extent, a combination of spectrometric/spectroscopic mapping/imaging methods with an inherent ability to provide a wealth of biochemical and physical information have been investigated to understand further the pathogenesis of brain disease. In this study, proton-induced X-ray emission (PIXE) mapping was combined with scanning transmission ion microscopy (STIM) mapping and Fourier-transform infrared (FTIR) imaging of the same tissue sample to study directly the composition of the murine (mouse) cerebellum. The combination of the elemental, density and molecular information provided by these techniques enabled differentiation between four specific tissue types within the murine cerebellum (grey matter, white matter, molecular layer and micro blood vessels). The results presented are complementary, multi-technique measurements of the same tissue sample. They show elemental, density and molecular differences among the different tissue types. (C) 2011 Elsevier B.V.en_AU
dc.identifier.citationHackett, M. J., Siegele, R., El-Assaad, F., McQuillan, J. A., Aitken, J.B., Carter, E. A., Grau, G. E., Hunt, N. H., Cohen, D., & Lay, P. A. (2011). Investigation of the mouse cerebellum using STIM and mu-PIXE spectrometric and FTIR spectroscopic mapping and imaging. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 269(20), 2260-2263. doi:10.1016/j.nimb.2011.02.034en_AU
dc.identifier.govdoc3764en_AU
dc.identifier.issn0168-583Xen_AU
dc.identifier.issue20en_AU
dc.identifier.journaltitleNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atomsen_AU
dc.identifier.pagination2260-2263en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.nimb.2011.02.034en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4152en_AU
dc.identifier.volume269en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectMappingen_AU
dc.subjectCerebellumen_AU
dc.subjectRatsen_AU
dc.subjectSpectroscopyen_AU
dc.subjectIon microscopyen_AU
dc.subjectEmissionen_AU
dc.titleInvestigation of the mouse cerebellum using STIM and mu-PIXE spectrometric and FTIR spectroscopic mapping and imagingen_AU
dc.typeJournal Articleen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles