New 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr.

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dc.contributor.authorDi Bartolo, Nen_AU
dc.contributor.authorSargeson, AMen_AU
dc.contributor.authorSmith, SVen_AU
dc.date.accessioned2010-11-10T05:05:52Zen_AU
dc.date.available2010-11-10T05:05:52Zen_AU
dc.date.issued2006-09-07en_AU
dc.date.statistics2006-09-07en_AU
dc.description.abstractThe success of positron emission tomography (PET) in personalised medicine and drug development requires radioisotopes that provide high quality images and flexible chemistry for a broad application. 64Cu is arguably one of the most suitable PET isotopes for imaging with the evolving target agents, but there are not many appropriate chelating agents for 64Cu and this has limited its wider application. The bi-functional chelator, SarAr is known to bind 64Cu2+ quantitatively (i.e. one metal per ligand present) and rapidly (<2 min) at 10−6 M over a range of pH (4–9). In this paper the conjugation of SarAr to the whole and fragmented antibody is described. Conjugation of the SarAr to the protein does not impair its coordination of the 64Cu. It complexes the 64Cu2+ rapidly, quantitatively and essentially irreversibly at pH 5. Animal studies show that the 64Cu–SarAr–immunoconjugates maintain their specificity for the target and are stable in vivo. Also, SarAr is a platform technology, is easy to use in a kit formulation and is readily adaptable for the wider application in 64Cu PET imaging. © 2006, Royal Society of Chemistryen_AU
dc.identifier.citationDi Bartolo, N., Sargeson , A. M., & Smith, S. V. (2006). New 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr. Organic & Biomolecular Chemistry, 17(4), 3350-3357. doi:10.1039/b605615fen_AU
dc.identifier.govdoc3045en_AU
dc.identifier.issn1477-0539en_AU
dc.identifier.issue4en_AU
dc.identifier.journaltitleOrganic & Biomolecular Chemistryen_AU
dc.identifier.pagination3350-3357en_AU
dc.identifier.urihttp://dx.doi.org/10.1039/b605615fen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2845en_AU
dc.identifier.volume17en_AU
dc.language.isoenen_AU
dc.publisherRoyal Society of Chemistryen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectCopper 64en_AU
dc.subjectRadioisotopesen_AU
dc.subjectChelating agentsen_AU
dc.subjectAntibodiesen_AU
dc.subjectDrugsen_AU
dc.titleNew 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr.en_AU
dc.typeJournal Articleen_AU
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