Molecular imaging with copper-64 in the drug discovery and development arena.

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dc.contributor.authorSmith, SVen_AU
dc.date.accessioned2010-10-21T03:24:25Zen_AU
dc.date.available2010-10-21T03:24:25Zen_AU
dc.date.issued2007-05-01en_AU
dc.date.statistics2007-05-01en_AU
dc.description.abstractThe contribution of positron emission tomography (PET) to the drug discovery and development (D3) pipeline has been inhibited by the short half-lifes of PET radioisotopes, 11C and 18F, poor availability and the high cost of infrastructure. Copper-64 (64Cu) has a 12.7 h half-life, simple yet flexible radiochemistry and imaging characteristics that make it ideal for a wider application across the D3 arena. Recent scientific breakthroughs in the production of 64Cu show that it's, commercial production can be made more widely available. More importantly, for pharmaceutical research and development programmes wishing to incorporate the high sensitivity and spatial resolution of PET, but no desire to implement and maintain expensive radiochemistry infrastructure, 64Cu is an exciting option. © 2007, Informa Healthcareen_AU
dc.identifier.citationSmith, S. V. (2007). Molecular imaging with copper-64 in the drug discovery and development arena. Expert Opinion on Drug Discovery, 2(5), 659-672. doi:10.1517/17460441.2.5.659en_AU
dc.identifier.govdoc2884en_AU
dc.identifier.issn1746-0441en_AU
dc.identifier.issue5en_AU
dc.identifier.journaltitleExpert Opinion on Drug Discoveryen_AU
dc.identifier.pagination659-672en_AU
dc.identifier.urihttp://dx.doi.org/10.1517/17460441.2.5.659en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2723en_AU
dc.identifier.volume2en_AU
dc.language.isoenen_AU
dc.publisherInforma Healthcareen_AU
dc.subjectDrugsen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectCopper 64en_AU
dc.subjectClinical trialsen_AU
dc.subjectImagesen_AU
dc.subjectRadiochemistryen_AU
dc.titleMolecular imaging with copper-64 in the drug discovery and development arena.en_AU
dc.typeJournal Articleen_AU
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