Sarar technology for the application of Copper-64 in biology and materials science

dc.contributor.authorSmith, SVen_AU
dc.date.accessioned2010-10-19T22:43:28Zen_AU
dc.date.available2010-10-19T22:43:28Zen_AU
dc.date.issued2007-04-29en_AU
dc.date.statistics2008-06en_AU
dc.description.abstractThis review provides an overview of the synthesis and metal complexation chemistry of the nitrogen and sulphur donor bicyclic ligands or cages, and the key criteria that led to the design of sarar for the application for 64Cu(II). Aspects of the high yielding synthesis of sarar and strategies for its conjugation to a range of antibodies for targeting colorectal cancer, neuroblastoma and melanoma are described. Free and conjugated to proteins sarar can complex 64Cu(II) rapidly at room temperature and quantitatively; the latter leading to products of high specific activity and purity. The full occupation of the 64Cu(II) ions 6 coordination sites by the sarar cage prevents the ready exchange of the 64Cu(II) from the cage and is the rational for the extraordinary thermodynamic and kinetic stability of 64Cu(II) labelled sarar and its conjugates. It’s in vivo stability is further highlighted by the low uptake and retention of 64Cu-sarar-conjugated antibodies in the liver. Finally, the prospects for the use of the sarar technology in the materials science arena for probing solid liquid interfaces, in particular, the quantification of functional groups on microspheres and in the engineering of novel materials are discussed. © 2008 Edizioni Minerva Medicaen_AU
dc.identifier.citationSmith, S. V. (2007). Sarar technology for the application of Copper-64 in biology and materials science. Paper presented to the 17th International Symposium on Radiopharmaceutical Sciences - "Production and Application of 'Non-Standard' PET Nuclides" Workshop, 30th April - 4th May 2007. In Quarterly Journal of Nuclear Medicine and Molecular Imaging, 52(2), 193-202.en_AU
dc.identifier.conferenceenddate4 May 2007en_AU
dc.identifier.conferencename17th International Symposium on Radiopharmaceutical Sciences - 'Design of In Vitro and In Vivo Studies - Opportunities and Challenges' Workshopen_AU
dc.identifier.conferenceplaceAachen, Germanyen_AU
dc.identifier.conferencestartdate30 April 2007en_AU
dc.identifier.govdoc2861en_AU
dc.identifier.issn1824-4661en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleQuarterly Journal of Nuclear Medicine and Molecular Imagingen_AU
dc.identifier.pagination193-202en_AU
dc.identifier.urihttp://www.minervamedica.it/en/journals/nuclear-med-molecular-imaging/article.php?cod=R39Y2008N02A0193en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2702en_AU
dc.identifier.volume52en_AU
dc.language.isoenen_AU
dc.publisherEdizioni Minerva Medicaen_AU
dc.subjectCopper 64en_AU
dc.subjectBiologyen_AU
dc.subjectMaterialsen_AU
dc.subjectNitrogenen_AU
dc.subjectLigandsen_AU
dc.subjectNeoplasmsen_AU
dc.titleSarar technology for the application of Copper-64 in biology and materials scienceen_AU
dc.typeConference Paperen_AU
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