Differential Treatment Regimen-Related Effects of HU210 on CB(1) and D(2)-Like Receptor Functionality in the Rat Basal Ganglia

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dc.contributor.authorNguyen, VHen_AU
dc.contributor.authorWang, Hen_AU
dc.contributor.authorVerdurand, Men_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2012-04-12T02:37:34Zen_AU
dc.date.available2012-04-12T02:37:34Zen_AU
dc.date.issued2012-02-01en_AU
dc.date.statistics2012-04-12en_AU
dc.description.abstractBackground/Aims: Functional linkages between the cannabinoid CB(1) and the dopaminergic systems have been reported although the observations and the mechanisms hypothesizing their interactions at the G protein-coupled receptor (GPCR) functionality level are conflicting. Methods: Administration of a potent cannabinoid agonist, HU210, at various doses (25-100 μg/kg) and treatment regimens (1- to 14-day treatment) in rats was carried out to investigate the effect of HU210 treatment on the CB(1) and D(2)-like agonist-mediated GPCR activation. Results: The desensitizations (reduced coupling) of both D(2) agonist- and CB(1) agonist-mediated GPCR activation was found to be treatment duration dependent and region specific, suggesting implication of receptor tolerance and adaptation due to the cannabinoid treatment. The effect of HU210 on the CB(1) agonist-mediated GPCR desensitization in all treatment groups was not dose dependent. Conclusions: The desensitization of D(2)-like receptors found after a cannabinoid treatment in this study strengthens the evidence that the two neurotransmitter systems interact at the intercellular level; this interaction might occur via multiple mechanisms, which also vary according to region. Copyright © 2012 S. Karger AG, Basel.en_AU
dc.identifier.citationNguyen, V.H., Wang, H., Verdurand, M., Zavitsanous, K. (2011). Differential Treatment Regimen-Related Effects of HU210 on CB(1) and D(2)-Like Receptor Functionality in the Rat Basal Ganglia. Pharmacology, 89(1-2), 64-73. doi:10.1159/000335368en_AU
dc.identifier.govdoc4182en_AU
dc.identifier.issn0031-7012en_AU
dc.identifier.issue1-2en_AU
dc.identifier.journaltitlePharmacologyen_AU
dc.identifier.pagination64-73en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4125en_AU
dc.identifier.urihttps://doi.org/10.1159/000335368en_AU
dc.identifier.volume89en_AU
dc.language.isoenen_AU
dc.publisherKargeren_AU
dc.subjectReceptorsen_AU
dc.subjectNeutron therapyen_AU
dc.subjectProteinsen_AU
dc.subjectRatsen_AU
dc.subjectBasal metabolismen_AU
dc.subjectAutoradiographyen_AU
dc.titleDifferential Treatment Regimen-Related Effects of HU210 on CB(1) and D(2)-Like Receptor Functionality in the Rat Basal Gangliaen_AU
dc.typeJournal Articleen_AU
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