Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: A small animal PET imaging study with (18)F-FDG

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dc.contributor.authorNguyen, VHen_AU
dc.contributor.authorVerdurand, Men_AU
dc.contributor.authorDedeurwaerdere, Sen_AU
dc.contributor.authorWang, HQen_AU
dc.contributor.authorZahra, Den_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2012-03-08T03:01:57Zen_AU
dc.date.available2012-03-08T03:01:57Zen_AU
dc.date.issued2012-02-10en_AU
dc.date.statistics2012-03-08en_AU
dc.description.abstractCannabis use has been shown to alter brain metabolism in both rat models and humans although the observations between both species are conflicting. In the present study, we examined the short term effects of a single-dose injection of the synthetic cannabinoid agonist HU210 on glucose metabolism in the rat brain using small animal (18)F-2-fluoro-deoxyglucose (FDG) Positron Emission Tomography (PET) 15min (Day 1) and 24h (Day 2) post-injection of the agonist in the same animal. Young adult male Wistar rats received an intra-peritoneal injection of HU210 (100μg/kg, n=7) or vehicle (n=5) on Day 1. Approximately 1mCi of (18)F-FDG was injected intravenously into each animal at 15min (Day 1) and 24h (Day 2) post-injection of HU210. A 5-min Computer Tomography (CT) scan followed by a 20-min PET scan was performed 40min after each (18)F-FDG injection. Standardised Uptake Values (SUVs) were calculated for 10 brain regions of interest (ROIs). Global increased SUVs in the whole brain, hence global brain metabolism, were observed following HU210 treatment on Day 1 compared to the controls (21%, P<0.0001), but not in individual brain regions. On Day 2, however, no statistically significant differences were observed between the treated and control groups. At the 24h time point (Day 2), SUVs in the HU210 treated group returned to control levels (21-30% decrease compared to Day 1), in all ROIs investigated (P<0.0001). In the control group, SUVs did not differ between the two acquisition days in all brain regions. The present results suggest that high-dose HU210 increases brain glucose metabolism in the rat brain shortly after administration, in line with normalised human in vivo studies, an effect that was no longer apparent 24h later. Copyright © 2011 Elsevier Inc. All rights reserved.en_AU
dc.identifier.citationNguyen, V. H., Verdurand, M., Dedeurwaerdere, S., Wang, H.Q., Zahra, D., Grégoire, M. C., & Zavitsanou, K. (2011). Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: A small animal PET imaging study with (18)F-FDG. Brain Research Bulletin, 87(2-3), 172-179. doi:10.1016/j.brainresbull.2011.11.011en_AU
dc.identifier.govdoc4181en_AU
dc.identifier.issn0361-9230en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleBrain Research Bulletinen_AU
dc.identifier.pagination172-179en_AU
dc.identifier.urihttps://doi.org/10.1016/j.brainresbull.2011.11.011en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4073en_AU
dc.identifier.volume87en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectBrainen_AU
dc.subjectMetabolismen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectRatsen_AU
dc.subjectReceptorsen_AU
dc.subjectGlucoseen_AU
dc.titleIncreased brain metabolism after acute administration of the synthetic cannabinoid HU210: A small animal PET imaging study with (18)F-FDGen_AU
dc.typeJournal Articleen_AU
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