Synthesis, characterization and application of zirconium and titanium inorganic polymer sorbents for the preparation of chromatographic 99mTc and 188Re generators
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Date
2007-10-08
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IAEA’s coordinated research project 3rd research coordination meeting
Abstract
The Zirconium polymer compound (PZC) and Titanium polymer compound (PTC) based adsorbents for the preparation of chromatographic 99mTc and 188Re generators were synthesized. Chemical composition, molecular structure and physicochemical characteristics of these adsorbents were investigated.
The adsorption propertiies of PZC and PTC sorbents in the different Molybdate and Tungstate solutions and the daughter nuclide elution performance were investigated. The Molybdenum adsorption capacities of about 275 mgMo/gPZC and 270 mgMo/gPTC and the 99mTc elution yield higher than 90% were achieved with both sorbents. The 99Mo breakthrough of 0.015% and Molybdenum element breakthrough lower than 2μg Mo/ml were found in the 99mTc eluate. The Tungsten adsorption capacities of about 520mgW/gPZC and 515 mgW/gPTC and the 188Re elution yield higher than 80% were also achieved with both PZC and PTC sorbents. The 188W breakthrough of 0.015% and Tungsten element breakthrough lower than 5 μg W /ml were found in the 188Re eluate.The parent nuclide adsorption capacity and the daughter nuclide elution performance of PTC sorbent resembled closely that of PZC one, except that the breakthrough of 99Mo and 188W parent nuclides was higher and PTC column needed smaller saline volume to elute 99mTc and 188Re daughter nuclides. The188Re eluate concentration process was developed by eluting 188Re from the tandem system of 188W-PTC – Alumina columns with the different concentration saline solutions. The concentration factor higher than 6 was achieved by this concentration technique which offered a potential application for the clinically applicable 188W-188Re generator production using low specific radioactivity 188W produced in rather low power research reactors.
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Keywords
Radioisotope generators, Zirconium compounds, Inorganic polymers, Adsorbents, Molecular structure, Chemical composition
Citation
Le, V.S. (2007). Synthesis, characterization and application of zirconium and titanium inorganic polymer sorbents for the preparation of chromatographic 99mTc and 188Re generators. IAEA’s coordinated research project 3rd research coordination meeting, 8th-12th October 2007. Daejeon, Korea.