The structure of TTHA0988 from thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase

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dc.contributor.authorJacques, DAen_AU
dc.contributor.authorLangley, DBen_AU
dc.contributor.authorKuramitsu, Sen_AU
dc.contributor.authorYokoyama, Sen_AU
dc.contributor.authorTrewhella, Jen_AU
dc.contributor.authorGuss, JMen_AU
dc.date.accessioned2011-08-18T01:36:43Zen_AU
dc.date.available2011-08-18T01:36:43Zen_AU
dc.date.issued2011-02-01en_AU
dc.date.statistics2011-08-18en_AU
dc.description.abstractThe Thermus thermophilus protein TTHA0988 is a protein of unknown function which represents a fusion of two proteins found almost ubiquitously across the bacterial kingdom. These two proteins perform a role regulating sporulation in Bacillus subtilis, where they are known as KipI and KipA. kipI and kipA genes are usually found immediately adjacent to each other and are often fused to produce a single polypeptide, as is the case with TTHA0988. Here, three crystal forms are reported of TTHA0988, the first structure to be solved from the family of `KipI-KipA fusion' proteins. Comparison of the three forms reveals structural flexibility which can be described as a hinge motion between the `KipI' and `KipA' components. TTHA0988 is annotated in various databases as a putative allophanate hydrolase. However, no such activity could be identified and genetic analysis across species with known allophanate hydrolases indicates that a misannotation has occurred. © 2011, Wiley-Blackwell. The definitive version is available at www3.interscience.wiley.comen_AU
dc.identifier.citationJacques, D.A., Langley, D.B., Kuramitsu, S., Yokoyama, S., Trewhella, J., Guss, J.M. (2011). The structure of TTHA0988 from thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase. Acta Crystallographica Section D: Structural Biological, 67(Part 2), 105-111. doi:10.1107/S0907444910051127en_AU
dc.identifier.govdoc3442en_AU
dc.identifier.issn0907-4449en_AU
dc.identifier.issuePart 2en_AU
dc.identifier.journaltitleActa Crystallographica Section D: Structural Biologicalen_AU
dc.identifier.pagination105-111en_AU
dc.identifier.urihttp://dx.doi.org/10.1107/S0907444910051127en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3699en_AU
dc.identifier.volume67en_AU
dc.language.isoenen_AU
dc.publisherWiley-Blackwellen_AU
dc.subjectProteinsen_AU
dc.subjectHydrolasesen_AU
dc.subjectBacillus subtilisen_AU
dc.subjectPolypeptidesen_AU
dc.subjectGenesen_AU
dc.subjectOrganic compoundsen_AU
dc.titleThe structure of TTHA0988 from thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolaseen_AU
dc.typeJournal Articleen_AU
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