Development of 68Ga generator at ANSTO

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dc.contributor.authorLe, VSen_AU
dc.contributor.authorIzard, Men_AU
dc.contributor.authorPellegrini, PAen_AU
dc.contributor.authorZaw, Men_AU
dc.date.accessioned2011-08-18T03:59:55Zen_AU
dc.date.available2011-08-18T03:59:55Zen_AU
dc.date.issued2011-06-23en_AU
dc.date.statistics2011-08-18en_AU
dc.description.abstractA 68 Ge/ 68 Ga generator combined with automated 68 Ga eluate purification unit was developed to produce 68 Ga solution suitable for labelling peptide ligands for PET radiopharmaceutical applications. The sorbent of a Ti-Zr ceramic structure [1] was used as a generator column packing material. 68 Ga eluate of around 5 mL volume in 0.1 M HCl solution was purified on a small cation exchanger column with an aqueous alcohol solution mixture of hydrochloric acid, ascorbic acids and halide salts. An alkali solution was used for elution of 68 Ga from the ion exchange resin column to obtain a purified 68 Ga solution which is conditioned with acidic solutions to obtain a final 68 Ga product of pH=3-4 in 0.75 mL 0.5 M NaCl or 0.5 M sodium acetate solution. The organic solvent free 68 Ga solution product of acidity suitable for coordination chemistry based labelling of the peptide ligands was successfully used for preparation of DOTATATE and DOTATOC PET radiopharmaceuticals. The process of 68 Ga elution from the generator followed by 68 Ga eluate purification was performed using a low-cost automation bench-top system. [2] This system is designed based on the timing sequence of seven processing steps without feedback control. The variable flow rate of eluents used for elution/purification in this system also ensure the optimisation of operating times with respect to different adsorption/ desorption kinetics of 68 Ga ion species, which is controlled by the sorbent and ion exchange resin used in the generator and purification columns. © 2011, Medknow publicationen_AU
dc.identifier.articlenumberP-023en_AU
dc.identifier.citationLe V.S., Izard M., Pellegrini P., Zaw M. (2011). Development of 68Ga generator at ANSTO. Poster presented to the 1st World Congress on Ga-68 and Peptide Receptor Radionuclide Therapy, THERANOSTICS, 23th -26th June 2011. Bad Berka, Germany. In World Journal of Nuclear Medicine, Abstracts of Poster Presentations (Chemistry), 10(1), 73-89.en_AU
dc.identifier.conferenceenddate26 June 2011en_AU
dc.identifier.conferencename1st World Congress on Ga-68 and Peptide Receptor Radionuclide Therapy, THERANOSTICSen_AU
dc.identifier.conferenceplaceBad Berka, Germanyen_AU
dc.identifier.conferencestartdate23 June 2011en_AU
dc.identifier.govdoc3561en_AU
dc.identifier.issn1450-1147en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleWorld Journal of Nuclear Medicineen_AU
dc.identifier.pagination73-89en_AU
dc.identifier.urihttp://www.wjnm.org/text.asp?2011/10/1/73/82109en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3701en_AU
dc.identifier.volume10en_AU
dc.language.isoenen_AU
dc.publisherMedknow Publicationsen_AU
dc.subjectRadioisotope generatorsen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectCeramicsen_AU
dc.subjectANSTOen_AU
dc.subjectGallium 68en_AU
dc.subjectLigandsen_AU
dc.titleDevelopment of 68Ga generator at ANSTOen_AU
dc.typeConference Posteren_AU
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