Specific radioactivity of neutron induced radioisotopes: assessment methods and application for medically useful 177Lu production as a case

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dc.contributor.authorLe, VSen_AU
dc.date.accessioned2011-03-08T00:30:52Zen_AU
dc.date.available2011-03-08T00:30:52Zen_AU
dc.date.issued2011-01-01en_AU
dc.date.statistics2011-01-01en_AU
dc.description.abstractThe conventional reaction yield evaluation for radioisotope production is not sufficient to set up the optimal conditions for producing radionuclide products of the desired radiochemical quality. Alternatively, the specific radioactivity (SA) assessment, dealing with the relationship between the affecting factors and the inherent properties of the target and impurities, offers a way to optimally perform the irradiation for production of the best quality radioisotopes for various applications, especially for targeting radiopharmaceutical preparation. Neutron-capture characteristics, target impurity, side nuclear reactions, target burn-up and post-irradiation processing/cooling time are the main parameters affecting the SA of the radioisotope product. These parameters have been incorporated into the format of mathematical equations for the reaction yield and SA assessment. As a method demonstration, the SA assessment of 177Lu produced based on two different reactions, 176Lu (n,γ)177Lu and 176Yb (n,γ) 177Yb (β- decay) 177Lu, were performed. The irradiation time required for achieving a maximum yield and maximum SA value was evaluated for production based on the 176Lu (n,γ)177Lu reaction. The effect of several factors (such as elemental Lu and isotopic impurities) on the 177Lu SA degradation was evaluated for production based on the 176Yb (n,γ) 177Yb (β- decay) 177Lu reaction. The method of SA assessment of a mixture of several radioactive sources was developed for the radioisotope produced in a reactor from different targets. © 2011, MDPI Publishingen_AU
dc.identifier.citationLe, V. S. (2011). Specific radioactivity of neutron induced radioisotopes: assessment methods and application for medically useful 177Lu production as a case. Molecules, 16(1), 818-846. doi:10.3390/molecules16010818en_AU
dc.identifier.govdoc3280en_AU
dc.identifier.issn1420-3049en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleMoleculesen_AU
dc.identifier.pagination818-846en_AU
dc.identifier.urihttp://dx.doi.org/10.3390/molecules16010818en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3122en_AU
dc.identifier.volume16en_AU
dc.language.isoenen_AU
dc.publisherMDPI Publishingen_AU
dc.subjectLutetium 177en_AU
dc.subjectRadioisotopesen_AU
dc.subjectRadioactivityen_AU
dc.subjectNuclear reaction yielden_AU
dc.subjectIsotope productionen_AU
dc.subjectIrradiationen_AU
dc.titleSpecific radioactivity of neutron induced radioisotopes: assessment methods and application for medically useful 177Lu production as a caseen_AU
dc.typeJournal Articleen_AU
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