Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer

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dc.contributor.authorChen, JZen_AU
dc.contributor.authorHuang, XFen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.date.accessioned2011-02-14T00:27:06Zen_AU
dc.date.available2011-02-14T00:27:06Zen_AU
dc.date.issued2010-12-01en_AU
dc.date.statistics2010-12-01en_AU
dc.description.abstractColorectal cancer is the third most common cancer with a 5-year survival rate of less than 10%. It is caused by alterations of multiple signal pathways which are affected by both genetic and environmental factors. In some cases, EGFR is important in the carcinogenesis of colorectal cancer suggesting anti-EGFR therapy may be a potential treatment option. However, in other cases it is not effective, which may be related to its down-stream targeted gene mutations. KRAS is highly emphasized in the literature but other mutations like Src, PIK3CA, and BRAF may also be important. Furthermore, obesity may decrease the effectiveness of anti-EGFR treatment as it increases the risk factors for colorectal cancer. Using next-generation sequencing technology, it may be possible to identify all gene mutations in an individual with colorectal cancer. Therefore, gene mutations affecting anti-EGFR therapy in colorectal cancer patients can be identified. © 2010, Wiley-Blackwell. The definitive version is available at www3.interscience.wiley.comen_AU
dc.identifier.citationChen, J. Z., Huang, X. F., & Katsifis, A. (2010). Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer. Journal of Cellular Biochemistry, 111(5), 1082-1086. doi:10.1002/jcb.22905en_AU
dc.identifier.govdoc3201en_AU
dc.identifier.issn0730-2312en_AU
dc.identifier.issue5en_AU
dc.identifier.journaltitleJournal of Cellular Biochemistryen_AU
dc.identifier.pagination1082-1086en_AU
dc.identifier.urihttp://dx.doi.org/10.1002/jcb.22905en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3008en_AU
dc.identifier.volume111en_AU
dc.language.isoenen_AU
dc.publisherWiley-Blackwellen_AU
dc.subjectNeoplasmsen_AU
dc.subjectCarcinogenesisen_AU
dc.subjectGrowth factorsen_AU
dc.subjectReceptorsen_AU
dc.subjectTherapyen_AU
dc.subjectGenome mutationsen_AU
dc.titleActivation of signal pathways and the resistance to anti-EGFR treatment in colorectal canceren_AU
dc.typeJournal Articleen_AU
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