Cannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210

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dc.contributor.authorDalton, VSen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2010-10-25T01:33:32Zen_AU
dc.date.available2010-10-25T01:33:32Zen_AU
dc.date.issued2010-11-01en_AU
dc.date.statistics2010-11-01en_AU
dc.description.abstractThe short- and long-term behavioral effects of cannabinoids differ in adolescent and adult rodents. Few studies though have examined the underlying neurochemical changes that occur in the brain following adolescent cannabinoid exposure. In this study, we examined the effect of treatment with the synthetic cannabinoid, HU210, on CB1 receptor density in the brain and on body weight in adolescent male rats. Rats were treated daily with 25, 50, or 100 μg/kg HU210 for 4 or 14 days, or received a single dose of 100 μg/kg HU210 and sacrificed 24 h later. Receptor density was investigated using in vitro autoradiography with the CB1 receptor ligand [3H] CP55,940. In contrast to adult animals treated under the same paradigm in a previous study, adolescents continued on average, to gain weight over the course of the study. Weight gain was slowest in the 100 μg/kg group and improved dose dependently with controls gaining the most weight. Following the acute dose of HU210, a trend for a reduction in [3H] CP55,940 binding and a significant effect of treatment was observed. Statistically significant, dose-dependent, region-specific decreases in binding were observed in all brain regions examined following 4 and 14 days treatment. The pattern of CB1 receptor downregulation was similar to that observed in adults treated with cannabinoids in previous studies; however, its magnitude was smaller in adolescents. This reduced compensatory response may contribute to some acute behavioral effects, the pharmacological cross-tolerance and the long-lasting, adverse psychological consequences of cannabinoid exposure during adolescence. © 2010, Wiley-Blackwell. The definitive version is available at www3.interscience.wiley.comen_AU
dc.identifier.citationDalton, V. S., & Zavitsanou, K. (2010). Cannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210. Synapse, 64(11), 845-854. doi:10.1002/syn.20801en_AU
dc.identifier.govdoc2923en_AU
dc.identifier.issn0887-4476en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitleSynapseen_AU
dc.identifier.pagination845-854en_AU
dc.identifier.urihttps://doi.org/10.1002/syn.20801en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2744en_AU
dc.identifier.volume64en_AU
dc.language.isoenen_AU
dc.publisherWiley-Blackwellen_AU
dc.subjectRatsen_AU
dc.subjectBehavioren_AU
dc.subjectBrainen_AU
dc.subjectReceptorsen_AU
dc.subjectWeighten_AU
dc.subjectAdolescentsen_AU
dc.titleCannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210en_AU
dc.typeJournal Articleen_AU
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