Interactions of cationic dendrigraft polymers with oligonucleotides and morphology of the resulting complexes.
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Date
2008-04-06
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Publisher
American Chemical Society
Abstract
The high density of negatively charged phosphate groups on ONs allows the formation of stable complexes with synthetic cationic polyelectrolytes (PEs). Even though DNA complexes with quaternized poly-vinylpyridine linear chains were previously reported to increase the efficiency of cell transformation, no report has been made for DNA complexes with dendrigraft PEs. For the current investigation, cationic dendrigraft polymers with pH-independent fully charged quaternized amine groups were synthesized. The structure of dendrigraft PEs and their complexes with ONs in solution was investigated by small-angle neutron scattering (SANS).
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Keywords
Small angle scattering, Oligonucleotides, DNA, Cell transformations, Morphology, Polymers
Citation
Yun, S. I., Hammerton, K., & Gauthier, M. (2008). Interactions of cationic dendrigraft polymers with oligonucleotides and morphology of the resulting complexes. Presentation to The 235th American Chemical Society (ACS) National Meeting, 6th - 10th April 2008. Morial Convention Center: New Orleans, LA. In Abstracts of scientific papers, 235th American Chemical Society national meeting & exposition : April 6-10, 2008, New Orleans, Louisiana, PMSE 422.