Thermally cross-linked PNVP films as antifouling coatings for biomedical applications

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dc.contributor.authorTelford, AMen_AU
dc.contributor.authorJames, Men_AU
dc.contributor.authorMeagher, Len_AU
dc.contributor.authorNeto, Cen_AU
dc.date.accessioned2010-09-01T05:24:32Zen_AU
dc.date.available2010-09-01T05:24:32Zen_AU
dc.date.issued2010-08-25en_AU
dc.date.statistics2010-08-25en_AU
dc.description.abstractProtein repellent coatings are widely applied to biomedical devices in order to reduce the nonspecific adhesion of plasma proteins, which can lead to failure of the device. Poly(N-vinylpyrrolidone) (PNVP) is a neutral, hydrophilic polymer with outstanding antifouling properties often used in these applications. In this paper, we characterize for the first time a cross-linking mechanism that spontaneously occurs in PNVP films upon thermal annealing. The degree of cross-linking of PNVP films and their solubility in water can be tailored by controlling the annealing, with no need for additional chemical treatment or irradiation. The physicochemical properties of the cross-linked films were investigated by X-ray photoelectron spectroscopy, infrared spectroscopy, neutron and X-ray reflectometry, ellipsometry, and atomic force microscopy, and a mechanism for the thermally induced cross-linking based on radical formation was proposed. The treated films are insoluble in water and robust upon immersion in harsh acid environment, and maintain the excellent protein-repellent properties of unmodified PNVP, as demonstrated by testing fibrinogen and immunoglobulin G adsorption with a quartz crystal microbalance. Thermal cross-linking of PNVP films could be exploited in a wide range of biotechnological applications to give antifouling properties to objects of any size, essentially making this an alternative to high-tech surface modification techniques. © 2010, American Chemical Societyen_AU
dc.identifier.citationTelford, A. M., James, M., Meagher, L., & Neto, C. (2010). Thermally cross-linked PNVP films as antifouling coatings for biomedical applications. ACS Applied Materials & Interfaces, 2(8), 2399-2408. doi:10.1021/am100406jen_AU
dc.identifier.govdoc2566en_AU
dc.identifier.issn1944-8244en_AU
dc.identifier.issue8en_AU
dc.identifier.journaltitleACS Applied Materials & Interfacesen_AU
dc.identifier.pagination2399-2408en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/am100406jen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2405en_AU
dc.identifier.volume2en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectCoatingsen_AU
dc.subjectCross-linkingen_AU
dc.subjectAntifoulantsen_AU
dc.subjectPlasmaen_AU
dc.subjectAnnealingen_AU
dc.subjectProteinsen_AU
dc.titleThermally cross-linked PNVP films as antifouling coatings for biomedical applicationsen_AU
dc.typeJournal Articleen_AU
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