Laboratory rat and mouse colonies: some implications for biomedical research.

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dc.contributor.authorMcNeill, JRen_AU
dc.date.accessioned2007-11-22T04:13:26Zen_AU
dc.date.accessioned2010-04-30T04:28:08Zen_AU
dc.date.available2007-11-22T04:13:26Zen_AU
dc.date.available2010-04-30T04:28:08Zen_AU
dc.date.issued1980-04en_AU
dc.description.abstractThe health of laboratory rodents has a significant bearing on experimental results; the use of healthy animal stock allows experiments to be completed without the complication of premature mortality. The first part of the report describes the implementation and management of germ-free and specific-pathogen-free rodent facilities at the AAEC Research Establishment. The second part is a comparative histological study of the lungs of germ-free rats and those reared conventionally. In animals autopsied over the period of 2 to 18 months it was found that there was little or no pathological change in the lungs of the germ-free rats whereas a progressive and serious deterioration was observed in the lungs of conventionally reared rats examined at similar time intervals. Some barrier-housed ex germ-free rats were similarly examined and found to be free from chronic respiratory disease.en_AU
dc.identifier.citationMcNeill, J. R. (1980) Laboratory rat and mouse colonies: some implications for biomedical research. (AAEC/E492). Lucas Heights, NSW: Research Establishment, Australian Atomic Energy Commission.en_AU
dc.identifier.govdoc96en_AU
dc.identifier.isbn0642596840en_AU
dc.identifier.otherAAEC-E-492en_AU
dc.identifier.placeofpublicationLucas Heights, New South Walesen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/140en_AU
dc.language.isoen_auen_AU
dc.publisherAustralian Atomic Energy Commissionen_AU
dc.subjectMiceen_AU
dc.subjectRatsen_AU
dc.subjectLungsen_AU
dc.subjectLaboratory animalsen_AU
dc.subjectGerm-free animalsen_AU
dc.titleLaboratory rat and mouse colonies: some implications for biomedical research.en_AU
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