Technetium-99 levels in pertechnetate solutions from (n,y) and (n,f) molybdenum-99 generators

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dc.contributor.authorMoore, PWen_AU
dc.date.accessioned2007-11-22T04:07:00Zen_AU
dc.date.accessioned2010-04-30T04:43:24Zen_AU
dc.date.available2007-11-22T04:07:00Zen_AU
dc.date.available2010-04-30T04:43:24Zen_AU
dc.date.issued1983-04en_AU
dc.description.abstractThere is increasing evidence that in some radiopharmaceutical kits Tc-99 has an adverse effect on the imaging and labelling performance of Tc-99m. For example labelling efficiency with red blood cells can be affected when 99/99m ratios exceed about 4:1. The 99/99m ratio in a target is about 13.5:1 after a seven-day irradiation in a nuclear reactor. The ratio increases slightly during the time needed for processing. With the chromatographic generators used in hospitals up to 90 hours may elapse between the final wash stage of manufacture and the first elution during which time 99/99m ratios can increase to about 90:1. If elution efficiencies are high and the time between elutions is between 12 and 24 hours ratios in the generator hence in the eluates may actually increase with each elution. In the case of ready-to-inject pertechnetate solutions the critical time at which 99/99m ratios increase rapidly is the time between elution and use. If production conditions are poor ratios may increase to more than 600:1 by the time of use. With better conditions and production schedules Tc-99 levels at the time of use are comparable to those from chromatographic generators.en_AU
dc.identifier.citationMoore, R. W. (1983). Technetium-99 levels in pertechnetate solutions from (n,y) and (n,f) molybdenum-99 generators. (AAEC/E565). Lucas Heights, NSW: Australian Atomic Energy Commission.en_AU
dc.identifier.govdoc985en_AU
dc.identifier.isbn0642597685en_AU
dc.identifier.otherAAEC-E-565en_AU
dc.identifier.placeofpublicationLucas Heights, New South Walesen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/54en_AU
dc.language.isoen_auen_AU
dc.publisherAustralian Atomic Energy Commissionen_AU
dc.subjectTechnetium 99en_AU
dc.subjectIsotope productionen_AU
dc.subjectNuclear decayen_AU
dc.subjectPertechnetatesen_AU
dc.titleTechnetium-99 levels in pertechnetate solutions from (n,y) and (n,f) molybdenum-99 generatorsen_AU
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