The development of dysprosium-165 hydroxide macroaggregates for radiation synovectomy

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dc.contributor.authorMcLaren, ABen_AU
dc.contributor.authorHetherington, ELRen_AU
dc.contributor.authorMaddalena, DJen_AU
dc.contributor.authorSnowdon, GMen_AU
dc.date.accessioned2007-11-22T04:25:59Zen_AU
dc.date.accessioned2010-04-30T04:37:12Zen_AU
dc.date.available2007-11-22T04:25:59Zen_AU
dc.date.available2010-04-30T04:37:12Zen_AU
dc.date.issued1988-06en_AU
dc.description.abstractThe development of a dysprosium-165 product Dy-HMA which is suitable for the radiation synovectomy of arthritic joints is described. Dysprosium-165 is a short-lived (t 1 /2 = 139 min) β-emitter produced by the neutron irradiation of natural dysprosium. Dy-HMA is a suspension of macroaggregated hydroxide particles in saline with the majority of particles in the 3-5 um range. Studies in rabbits have demonstrated minimal leakage following the intra-articular injection of a knee joint. At 24 hours the accumulation in the liver is about 0.003% of the injected dose and there is considerably less in other organs and tissue. The use of Dy-HMA has considerable advantages over the presently used yttrium-90 products. The undesired leakage to and subsequent irradiation of other organs is considerably reduced. The period of hospitalisation is reduced from four days to one and the production of 165 Dy in Australia will overcome the difficulties of supply 90Y from overseas.en_AU
dc.identifier.citationMcLaren, A. B., Hetherington, E. L. R., Maddalena, D. J., & Snowdon, G. M. (1988). The development of dysprosium-165 hydroxide macroaggregates for radiation synovectomy. (ANSTO/E673). Lucas Heights, NSW: Australian Nuclear Science and Technology Organisationen_AU
dc.identifier.govdoc600en_AU
dc.identifier.issn10307745en_AU
dc.identifier.otherANSTO-E-673en_AU
dc.identifier.placeofpublicationLucas Heights, New South Walesen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/590en_AU
dc.language.isoen_auen_AU
dc.publisherAustralian Nuclear Science and Technology Organisationen_AU
dc.subjectDysprosium 165 targeten_AU
dc.subjectBone jointsen_AU
dc.subjectNeutron dosimetryen_AU
dc.subjectRabbitsen_AU
dc.subjectIrradiationen_AU
dc.titleThe development of dysprosium-165 hydroxide macroaggregates for radiation synovectomyen_AU
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