Ultrastructure changes produced by the action of uranyl acetate on the human erythrocyte in vitro

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dc.contributor.authorWyatt, JHen_AU
dc.date.accessioned2007-11-22T04:24:36Zen_AU
dc.date.accessioned2010-04-30T04:36:29Zen_AU
dc.date.available2007-11-22T04:24:36Zen_AU
dc.date.available2010-04-30T04:36:29Zen_AU
dc.date.issued1975-06en_AU
dc.description.abstractHuman erythrocytes exposed in vitro to low concentrations of uranyl ions are immediately changed in shape to stomatocytes. Electron microscope examination demonstrates that cellular damage is confined to the plasma membrane. Endocytosis of the cell membrane produces groups of inside out membrane-lined vesicles within the cell; lipid from the membrane enters the cell, giving rise to intracellular myelin figures, and breaks are seen in the cell membrane. The degree and type of change is shown to be a dose-dependent phenomenon. It is proposed that the lipid fraction of the cell membrane is the primary target for damage by uranyl ions.en_AU
dc.identifier.citationWyatt, J. H. (1975). Ultrastructure changes produced by the action of uranyl acetate on the human erythrocyte in vitro. (AAEC/E346). Lucas Heights, NSW: Australian Atomic Energy Commission.en_AU
dc.identifier.govdoc562en_AU
dc.identifier.isbn0642996741en_AU
dc.identifier.otherAAEC-E-346en_AU
dc.identifier.placeofpublicationLucas Heights, New South Walesen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/552en_AU
dc.language.isoen_auen_AU
dc.publisherAustralian Atomic Energy Commissionen_AU
dc.subjectUranyl compoundsen_AU
dc.subjectErythrocytesen_AU
dc.subjectElectron microscopyen_AU
dc.subjectAnimal cellsen_AU
dc.subjectCell membranesen_AU
dc.titleUltrastructure changes produced by the action of uranyl acetate on the human erythrocyte in vitroen_AU
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