Understanding the interaction between the proteus mirabilis Scs proteins using neutron scattering

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dc.contributor.authorFurlong, Een_AU
dc.contributor.authorWhitten, AEen_AU
dc.contributor.authorChoudhury, Hen_AU
dc.contributor.authorKurth, Fen_AU
dc.contributor.authorDuff, APen_AU
dc.contributor.authorMartin, JMen_AU
dc.date.accessioned2024-01-11T05:10:38Zen_AU
dc.date.available2024-01-11T05:10:38Zen_AU
dc.date.issued2018-11-18en_AU
dc.date.statistics2023-05-25en_AU
dc.description.abstractCorrectly forming disulphide bonds is critical to the folding of a wide variety of proteins. Bacterial virulence factors are one class of proteins containing disulfide bonds, thus, an approach to disarm virulent bacterial might involve shutting down the machinery involved in the formation of disulfide bonds. The suppressor of copper sensitivity (Scs) proteins form part of the disulfide bond forming machinery in bacteria, and it is hoped that determining the structure of molecules such as this may lead to the development of new classes of antibiotics. There are four Scs proteins (ScsA, B, C and D) present in numerous Gram-negative bacteria, and few have been structurally characterised. In this work, we have created cysteine variants of PmScsC and PmScsB to produce a stable complex and using small-angle X-ray and neutron scattering with contrast variation, we have determined the low-resolution structure of the PmScsC–PmScsB complex. © The authors.en_AU
dc.identifier.citationFurlong, E., Whitten, A., Choudhury, H., Kurth, F., Duff, A., & Martin, J. (2018). Understanding the interaction between the proteus mirabilis Scs proteins using neutron scattering. Presentation to the ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018, AINSE Conference Centre New Illawarra Road Lucas Heights NSW 2234, Australia, Monday 19 November 2018 - Wednesday 21 November 2018, (pp. 12- 13). Retrieved from https://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.identifier.conferenceenddate2018-11-21en_AU
dc.identifier.conferencenameANBUG-AINSE Neutron Scattering Symposium, AANSS 2018en_AU
dc.identifier.conferenceplaceLucas Heights, New South Walesen_AU
dc.identifier.conferencestartdate2018-11-19en_AU
dc.identifier.pagination12-13en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15319en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineering (AINSE)en_AU
dc.relation.urihttps://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.subjectProteinsen_AU
dc.subjectDisulfidesen_AU
dc.subjectBondingen_AU
dc.subjectVirulenceen_AU
dc.subjectCopperen_AU
dc.subjectMoleculesen_AU
dc.subjectNeutronsen_AU
dc.subjectScatteringen_AU
dc.subjectCysteineen_AU
dc.titleUnderstanding the interaction between the proteus mirabilis Scs proteins using neutron scatteringen_AU
dc.typeConference Abstracten_AU
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