Propagation-based x-ray phase-contrast tomography of mastectomy samples using synchrotron radiation

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dc.contributor.authorGureyev, TEen_AU
dc.contributor.authorNesterets, YIen_AU
dc.contributor.authorBaran, PMen_AU
dc.contributor.authorTaba, STen_AU
dc.contributor.authorMayo, SCen_AU
dc.contributor.authorThompson, Den_AU
dc.contributor.authorArhatari, BDen_AU
dc.contributor.authorMihocic, Aen_AU
dc.contributor.authorAbbey, Ben_AU
dc.contributor.authorLockie, Den_AU
dc.contributor.authorFox, Jen_AU
dc.contributor.authorKumar, Ben_AU
dc.contributor.authorProdanovic, Zen_AU
dc.contributor.authorHäusermann, Den_AU
dc.contributor.authorMaksimenko, Aen_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorPeele, AGen_AU
dc.contributor.authorDimmock, MRen_AU
dc.contributor.authorPavlov, KMen_AU
dc.contributor.authorCholewa, Men_AU
dc.contributor.authorLewis, SJen_AU
dc.contributor.authorTromba, Gen_AU
dc.contributor.authorQuiney, HMen_AU
dc.contributor.authorBrennan, PCen_AU
dc.date.accessioned2023-11-27T23:47:17Zen_AU
dc.date.available2023-11-27T23:47:17Zen_AU
dc.date.issued2019-10-01en_AU
dc.date.statistics2023-04-27en_AU
dc.description.abstractPurpose Propagation-based phase-contrast computed tomography (PB-CT) is a method for three-dimensional x-ray imaging that utilizes refraction, as well as absorption, of x rays in the tissues to increase the signal-to-noise ratio (SNR) in the resultant images, in comparison with equivalent conventional absorption-only x-ray tomography (CT). Importantly, the higher SNR is achieved without sacrificing spatial resolution or increasing the radiation dose delivered to the imaged tissues. The present work has been carried out in the context of the current development of a breast CT imaging facility at the Australian Synchrotron. Methods Seven unfixed complete mastectomy samples with and without breast cancer lesions have been imaged using absorption-only CT and PB-CT techniques under controlled experimental conditions. The radiation doses delivered to the mastectomy samples during the scans were comparable to those approved for mammographic screening. Physical characteristics of the reconstructed images, such as spatial resolution and SNR, have been measured and compared with the results of the radiological quality assessment of the complete absorption CT and PB-CT image stacks. Results Despite the presence of some image artefacts, the PB-CT images have outperformed comparable absorption CT images collected at the same radiation dose, in terms of both the measured objective image characteristics and the radiological image scores. The outcomes of these experiments are shown to be consistent with predictions of the theory of PB-CT imaging and previous reported experimental studies of this imaging modality. Conclusions The results presented in this paper demonstrate that PB-CT holds a high potential for improving on the quality and diagnostic value of images obtained using existing medical x-ray technologies, such as mammography and digital breast tomosynthesis (DBT). If implemented at suitable synchrotron imaging facilities, PB-CT can be used to complement existing imaging modalities, leading to more accurate breast cancer diagnosis. © 2023 American Association of Physicists in Medicineen_AU
dc.description.sponsorshipThis research was undertaken on the Imaging and Medical beamline at the Australian Synchrotron, part of ANSTO. The following funding is acknowledged: Australian National Breast Cancer Foundation (grant No. IN-16-001), and Project Grant APP1138283 from the National Health and Medical Research Council (NHMRC), Australia.en_AU
dc.identifier.citationGureyev, T. E., Nesterets, Y. I., Baran, P. M., Taba, S. T., Mayo, S. C., Thompson, D., Arhatari, B., Mihocic, A., Abbey, B., Lockie, D., Fox, J., Kumar, B., Prodanovic, Z., Hausermann, D., Maksimenko, A., Hall, C., Peele, A. G., Dimmock, M., Pavlov, K. M., Cholewa, M., Lewis, S., Tromba, G., Quiney, H. M., & Brennan, P. C. (2019). Propagation-based x-ray phase-contrast tomography of mastectomy samples using synchrotron radiation. Medical Physics, 46(12), 5478-5487. doi:10.1002/mp.13842en_AU
dc.identifier.issn0094-2405en_AU
dc.identifier.issue12en_AU
dc.identifier.journaltitleMedical Physicsen_AU
dc.identifier.pagination5478-5487en_AU
dc.identifier.urihttps://doi.org/10.1002/mp.13842en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15246en_AU
dc.identifier.volume46en_AU
dc.language.isoenen_AU
dc.publisherAmerican Association of Physicists in Medicineen_AU
dc.relation.urihttps://doi.org/10.1002/mp.13842en_AU
dc.subjectTomographyen_AU
dc.subjectContrast mediaen_AU
dc.subjectMammary glandsen_AU
dc.subjectSynchrotron radiationen_AU
dc.subjectImagesen_AU
dc.subjectSignal-to-noise-ratioen_AU
dc.subjectANSTOen_AU
dc.subjectSynchrotronsen_AU
dc.subjectNeoplasmsen_AU
dc.titlePropagation-based x-ray phase-contrast tomography of mastectomy samples using synchrotron radiationen_AU
dc.typeJournal Articleen_AU
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