First 26Al analyses at the ANTARES AMS Centre: uptake via oral ingestion of 26Al in rats

Fink, D; Walton, J; Hotchkis, MAC; Jacobsen, GE; Lawson, EM; Smith, AM; Tuniz, C; Wilcox, D

First 26Al analyses at the ANTARES AMS Centre: uptake via oral ingestion of 26Al in rats

Date

1994-06-03

Authors

Publisher

Elsevier

Abstract

As the debate on the role played by aluminium in Alzheimer's disease remains a controversial one, the mechanism and degree of uptake of aluminium into brain tissue is not well understood nor quantified. We report here results from the initial phase of our study of aluminium uptake and retention in tissues of rats following oral administration of a tracer dose of 26Al. An account of our biomedical findings in old rats will be described elsewhere. For a young rat population, we find 26Al retention in the liver to be 7 times that in the brain. A description of our experience in performing aluminium measurements of biological tissues is described and interpretation of the findings are given. © 1994 Elsevier B.V.

Keywords

Aluminium, Diseases, Brain, Rats, Animal tissues, Liver, ANTARES Tandem Accelerator

Citation

Fink, D., Walton, J., Hotchkis, M. A. C., Jacobsen, G. E., Lawson, E. M., Smith, A. M., Tuniz, C., & Wilcox, D. (1994). First 26Al analyses at the ANTARES AMS Centre: uptake via oral ingestion of 26Al in rats. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 92(1–4), 473-477. doi:10.1016/0168-583X(94)96057-7