A general synthesis of 7-Phenyl-7,13-dihydro-8H-benzo[6,7]azepino[3,2-c]quinolin-8-ones

Dobrowolski, JC; Nguyen, DHT; Fraser, BH; Bhadbhade, MM; Black, DS; Kumar, N

A general synthesis of 7-Phenyl-7,13-dihydro-8H-benzo[6,7]azepino[3,2-c]quinolin-8-ones

Date

2019-02-13

Authors

Publisher

Thieme

Abstract

Complex benzazepinoquinolone scaffolds can be accessed from the reaction of 2-aminoacetophenones and oxindole derivatives and feature the seven-membered azepine ring moiety commonly found in a range of drug molecules. The described reaction is generally applicable and allows for rapid access to a diverse range of new structures with further potential to build more elaborate molecules. © 2021 Georg Thieme Verlag KG

Keywords

Heterocyclic compounds, Dehydrocyclization, Quinolines, Drugs, Molecules, Chemical reactions

Citation

Dobrowolski, J. C., Nguyen, D. H. T., Fraser, B. H., Bhadbhade, M., Black, D. S., & Kumar, N. (2019). A general synthesis of 7-Phenyl-7,13-dihydro-8H-benzo[6,7]azepino[3,2-c]quinolin-8-ones. Synlett, 30(05), 567-572. doi:10.1055/s-0037-1612106