A novel anthropomorphic phantom composed of tissue-equivalent materials for use in experimental radiotherapy: design, dosimetry and biological pilot study

Simple item page
dc.contributor.authorBreslin, Ten_AU
dc.contributor.authorPaino, JRen_AU
dc.contributor.authorWegner, Men_AU
dc.contributor.authorEngels, Een_AU
dc.contributor.authorFiedler, Sen_AU
dc.contributor.authorForrester, HBen_AU
dc.contributor.authorRennau, Hen_AU
dc.contributor.authorBustillo, Jen_AU
dc.contributor.authorCameron, Men_AU
dc.contributor.authorHäusermann, Den_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorKrause, Den_AU
dc.contributor.authorHildebrandt, Gen_AU
dc.contributor.authorLerch, MLFen_AU
dc.contributor.authorSchültke, Een_AU
dc.date.accessioned2025-03-06T05:01:23Zen_AU
dc.date.available2025-03-06T05:01:23Zen_AU
dc.date.issued2023-04-26en_AU
dc.date.statistics2025-03-05en_AU
dc.description.abstractThe production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells. © 2023 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licence.en_AU
dc.description.sponsorshipThis work was supported by a STINT Mobility Grant to T.B., a DAAD exchange grant to E.S. and M.L. (PPP 57650979), by a DFG grant to E.S. (SCHU 2589/7) and the ANSTO AS IMBL Beamtime Award 19173 to E.S.en_AU
dc.format.mediumElectronicen_AU
dc.identifier.articlenumber230en_AU
dc.identifier.citationBreslin, T., Paino, J., Wegner, M., Engels, E., Fiedler, S., Forrester, H., Rennau, H., Bustillo, J., Cameron, M., Häusermann, D., Hall, C., Krause, D., Hildebrandt, G., Lerch, M., & Schültke, E. (2023). A novel anthropomorphic phantom composed of tissue-equivalent materials for use in experimental radiotherapy: design, dosimetry and biological pilot study. Biomimetics, 8(2), 230. doi:10.3390/biomimetics8020230en_AU
dc.identifier.issn2313-7673en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleBiomimeticsen_AU
dc.identifier.urihttps://doi.org/10.3390/biomimetics8020230en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16024en_AU
dc.identifier.volume8en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherMDPIen_AU
dc.subjectRadiotherapyen_AU
dc.subjectPhantomsen_AU
dc.subjectMelanomasen_AU
dc.subjectIrradiationen_AU
dc.subjectSynchrotronsen_AU
dc.subjectCorrelationsen_AU
dc.subjectPhoton computed tomographyen_AU
dc.subjectDosimetryen_AU
dc.subjectTherapyen_AU
dc.subjectPatientsen_AU
dc.subjectDose limitsen_AU
dc.titleA novel anthropomorphic phantom composed of tissue-equivalent materials for use in experimental radiotherapy: design, dosimetry and biological pilot studyen_AU
dc.typeJournal Articleen_AU
dcterms.dateAccepted2023-05-28en_AU
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy Design, Dosimet.pdf
Size:
2.58 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.66 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles