P219 / #908 - advancements in NCEPT: animal study outcomes and technological developments toward clinical application

Simple item page
dc.contributor.authorHirayama, Ren_AU
dc.contributor.authorTashima, Hen_AU
dc.contributor.authorHamato, Aen_AU
dc.contributor.authorHowell, NRen_AU
dc.contributor.authorSierro, Fen_AU
dc.contributor.authorKielly, Men_AU
dc.contributor.authorCaracciolo, Aen_AU
dc.contributor.authorFranklin, DRen_AU
dc.contributor.authorGuatelli, Sen_AU
dc.contributor.authorYamaya, Ten_AU
dc.contributor.authorRosenfeld, ABen_AU
dc.contributor.authorFiorini, Cen_AU
dc.contributor.authorCarminati, Men_AU
dc.contributor.authorSafavi-Naeini, Men_AU
dc.date.accessioned2025-01-12T22:13:51Zen_AU
dc.date.available2025-01-12T22:13:51Zen_AU
dc.date.issued2024-06en_AU
dc.date.statistics2024-10-23en_AU
dc.description.abstractBackground and aims: Neutron Capture Enhanced Particle Therapy (NCEPT) represents a promising advancement in cancer treatment, utilising neutron capture agents (NCAs) to enhance therapeutic efficacy of proton/heavy ion radiation. This work focuses on animal experiments and concurrent technological developments aimed at translating NCEPT into clinical practice. Methods: Animal studies were conducted to assess the therapeutic impact of NCEPT. Baseline dose response of U87MG xenograft Balb/c nu/nu mice to 12C and 4He ion radiation was evaluated at HIMAC (February 2021, January 2022). NCEPT dose-response experiments with 10B-BPA as the NCA and using the same animal model were conducted in two campaigns in 2023. 200 mice were irradiated with helium or carbon ions across four dose levels (0 Gy, 5 Gy, 10 Gy, and 15 Gy, n = 6 mice/ion/dose); tumour growth was measured at different time points. In parallel, a scintillator-based detector for measurement of photon spectrum changes due to neutron capture was developed and evaluated in simulations and experiments with boron-loaded PMMA targets irradiated by helium/carbon ion beams. Results: Baseline experiments showed expected dose-response relationships, with tumour response and measured neutron fluence informing the NCEPT study protocol. NCEPT experiments demonstrated significant tumour volume reductions (33%/46% for helium/carbon ion irradiation, respectively) and delays in tumour growth relative to baseline. The prototype detector measured increases in the area of the 478 keV peak by 26%/45% for helium/carbon beams, respectively, compared to simulation-based values of 57%/45%. >65% of these photons originated from 10B captures in the detector's PCB, highlighting the need for neutron shielding and boron-free materials in detector construction. The linear increase in neutron capture photons at 10B concentrations up to 20000 ppm, with potential for detection down to 100 ppm using temporal windowing, paves the way for a SPECT-like neutron capture imaging system, crucial for NCEPT quality assurance. Conclusion: The combined animal study outcomes and technological advancements underscore the potential of NCEPT as a highly effective cancer therapy. The progress in dosimetry and imaging techniques mark significant steps toward the clinical translation of NCEPT, promising improved patient outcomes in cancer treatment. © 2024 Elsevier B.V. Open Access under a CC-BY-NC-ND 4.0 licenceen_AU
dc.identifier.articlenumber100603en_AU
dc.identifier.citationHirayama, R., Tashima, H., Hamato, A., Howell, N., Sierro, F., Kielly, M., Caracciolo, A., Franklin, D., Guatelli, S., Yamaya, T., Rosenfeld, A., Fiorini, C., Carminati, M., & Mitra. (2024). P219 / #908 - advancements in NCEPT: animal study outcomes and technological developments toward clinical application. Presentation to the 62nd Annual Conference of the Particle Therapy Cooperative Group. and the 4th PTCOG-AO, 10-15 June, 2024, Singapore. In International Journal of Particle Therapy, 12, 100603. doi:10.1016/j.ijpt.2024.100603en_AU
dc.identifier.conferenceenddate2024-06-15en_AU
dc.identifier.conferencename62nd Annual Conference of the Particle Therapy Cooperative Group and the 4th PTCOG-AOen_AU
dc.identifier.conferenceplaceSingaporeen_AU
dc.identifier.conferencestartdate2024-06-10en_AU
dc.identifier.issn2331-5180en_AU
dc.identifier.journaltitleInternational Journal of Particle Therapyen_AU
dc.identifier.urihttps://doi.org/10.1016/j.ijpt.2024.100603en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15912en_AU
dc.identifier.volume12en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectProtonsen_AU
dc.subjectIonsen_AU
dc.subjectAnimalsen_AU
dc.subjectHeliumen_AU
dc.subjectCarbonen_AU
dc.subjectTestingen_AU
dc.subjectNeoplasmsen_AU
dc.subjectIon beamsen_AU
dc.titleP219 / #908 - advancements in NCEPT: animal study outcomes and technological developments toward clinical applicationen_AU
dc.typeConference Abstracten_AU
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S2331518024006693-main (1).pdf
Size:
257.88 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.66 KB
Format:
Plain Text
Description:
Download
Collections
Conference Publications